PP2A-Cα/β Antibody (1D6): sc-80665

PP2A-Cα/β Antibody (1D6) is a mouse monoclonal IgG2b kappa light chain antibody that detects PP2A-Cα/β of mouse, rat, human, bovine, porcine, and canine origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-PP2A-Cα/β antibody (1D6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PP2A-Cα/β plays a crucial role in cellular signaling by acting as a serine/threonine phosphatase, which is essential for regulating numerous cellular processes such as cell division, differentiation, and apoptosis. PP2A-Cα/β is primarily located in the cytoplasm and nucleus, where PP2A-Cα/β interacts with various substrates to modulate their phosphorylation status, thereby influencing key signaling pathways. Proper functioning of PP2A-Cα/β is vital for maintaining cellular homeostasis, and dysregulation has been implicated in various diseases, including cancer and neurodegenerative disorders. PP2A family consists of multiple regulatory subunits that can associate with the catalytic subunit, allowing for a diverse range of functional outcomes depending on the specific cellular context. Using PP2A-Cα/β (1D6) antibody in research can provide valuable insights into the intricate regulatory mechanisms governed by this important phosphatase.

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PP2A-Cα/β Antibody (1D6) References:

1. Structure and expression of two isoforms of the murine calmodulin-dependent protein phosphatase regulatory subunit (calcineurin B).  |  Ueki, K., et al. 1992. Biochem Biophys Res Commun. 187: 537-43. PMID: 1325794
2. The Interplay between PP2A and microRNAs in Leukemia.  |  Ruvolo, PP. 2015. Front Oncol. 5: 43. PMID: 25750899
3. Protein Phosphatase 2A (PP2A) mutations in brain function, development, and neurologic disease.  |  Verbinnen, I., et al. 2021. Biochem Soc Trans. 49: 1567-1588. PMID: 34241636
4. Biased holoenzyme assembly of protein phosphatase 2A (PP2A): From cancer to small molecules.  |  Haanen, TJ., et al. 2022. J Biol Chem. 298: 102656. PMID: 36328247
5. PAK6-mediated phosphorylation of PPP2R2C regulates LRRK2-PP2A complex formation.  |  Iannotta, L., et al. 2023. Front Mol Neurosci. 16: 1269387. PMID: 38169846
6. PP2A-B55 phosphatase counteracts Ki-67-dependent chromosome individualization during mitosis.  |  Sanz-Flores, M., et al. 2024. Cell Rep. 43: 114494. PMID: 39003739
7. Molecular cloning of NIPP-1, a nuclear inhibitor of protein phosphatase-1, reveals homology with polypeptides involved in RNA processing.  |  Van Eynde, A., et al. 1995. J Biol Chem. 270: 28068-74. PMID: 7499293
8. Serine/threonine protein phosphatases.  |  Wera, S. and Hemmings, BA. 1995. Biochem J. 311 (Pt 1): 17-29. PMID: 7575450
9. Important roles for novel protein phosphatases dephosphorylating serine and threonine residues.  |  Cohen, PT. 1993. Biochem Soc Trans. 21: 884-8. PMID: 8132087
10. A regulatory subunit of smooth muscle myosin bound phosphatase.  |  Okubo, S., et al. 1994. Biochem Biophys Res Commun. 200: 429-34. PMID: 8166716
11. Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing.  |  Hendrix, P., et al. 1993. J Biol Chem. 268: 15267-76. PMID: 8392071
12. Protein serine/threonine phosphatases: structure, regulation, and functions in cell growth.  |  Mumby, MC. and Walter, G. 1993. Physiol Rev. 73: 673-99. PMID: 8415923

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PP2A-Cα/β Antibody (1D6) has 34 citations in a variety of scientific publications.

Primary antibodies like Anti-PP2A-Cα/β Antibody (1D6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PP2A-Cα/β Antibody (1D6) Specifications

Alternate Product Name: PP2A phosphatase catalytic subunit C alpha/beta

Product Clone Name: 1D6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 295-309

Epitope Target: PP2A-Cα/β

Epitope Species: human

Product Reactivity/Detection: PP2A-Cα/β

Species Reactivity/Detection: mouse, rat, human, bovine, porcine, canine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: bacterial

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 34 citations in various scientific publications

Available Conjugates/Forms for PP2A-Cα/β Antibody (1D6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred p-PP2A-Cα/β antibody is p-PP2A-Cα/β Antibody (F-8): sc-271903.