PP2A-B56-δ Antibody (H-11): sc-271363
- PP2A-B56-δ Antibody (H-11) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 509-573 mapping near the C-terminus of PP2A-B56-δ of human origin
- recommended for detection of PP2A-B56-δ of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for PP2A-B56-δ Antibody (H-11) for WB applications. These reagents are now offered in bundles with PP2A-B56-δ Antibody (H-11) (see ordering information below).
QUICK LINKS
SEE ALSO...
PP2A-B56-δ Antibody (H-11) is a mouse monoclonal IgG1 antibody that detects PP2A-B56-δ in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PP2A-B56-δ is a regulatory subunit of the protein phosphatase 2A (PP2A) complex, which plays a crucial role in various cellular processes, including cell growth, division, and apoptosis. PP2A-B56-δ modulates PP2A holoenzyme activity through a trimeric complex composed of regulatory, variable, and catalytic subunits. PP2A-B56-δ specifically influences substrate specificity and cellular localization, impacting target protein dephosphorylation in critical signaling pathways. PP2A-B56-δ interactions with other subunits form distinct PP2A complexes targeting specific substrates, maintaining cellular homeostasis and responding to stress signals. PP2A-B56-δ regulates diverse cellular functions, highlighting significance in normal physiology and disease states, including cancer, where phosphatase activity dysregulation can lead to aberrant signaling and tumor progression.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PP2A-B56-δ Antibody (H-11) References:
- Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1. | Forester, CM., et al. 2007. Proc Natl Acad Sci U S A. 104: 19867-72. PMID: 18056802
- Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers. | Roberts, KG., et al. 2010. Cancer Res. 70: 5438-47. PMID: 20551067
- ATM-mediated phosphorylation activates the tumor-suppressive function of B56γ-PP2A. | Shouse, GP., et al. 2011. Oncogene. 30: 3755-65. PMID: 21460856
- Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta. | Louis, JV., et al. 2011. Proc Natl Acad Sci U S A. 108: 6957-62. PMID: 21482799
- Ser70 phosphorylation of Bcl-2 by selective tyrosine nitration of PP2A-B56δ stabilizes its antiapoptotic activity. | Low, IC., et al. 2014. Blood. 124: 2223-34. PMID: 25082878
- Evolutionary Analysis of the B56 Gene Family of PP2A Regulatory Subunits. | Sommer, LM., et al. 2015. Int J Mol Sci. 16: 10134-57. PMID: 25950761
- Endogenous PP2A inhibitor CIP2A degradation by chaperone-mediated autophagy contributes to the antitumor effect of mitochondrial complex I inhibition. | Cazzoli, R., et al. 2023. Cell Rep. 42: 112616. PMID: 37289585
- Differential Synonymous Codon Selection in the B56 Gene Family of PP2A Regulatory Subunits. | Corzo, G., et al. 2023. Int J Mol Sci. 25: PMID: 38203563
- The role of liprin-α1 phosphorylation in its liquid-liquid phase separation: regulation by PPP2R5D/PP2A holoenzyme. | Mayer, A., et al. 2024. bioRxiv.. PMID: 38948786
- The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm. | McCright, B., et al. 1996. J Biol Chem. 271: 22081-9. PMID: 8703017
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PP2A-B56-δ Antibody (H-11) | sc-271363 | 200 µg/ml | $322.00 | |||
PP2A-B56-δ Antibody (H-11): m-IgG Fc BP-HRP Bundle | sc-540229 | 200 µg Ab; 10 µg BP | $361.00 | |||
PP2A-B56-δ Antibody (H-11): m-IgG1 BP-HRP Bundle | sc-541985 | 200 µg Ab; 20 µg BP | $361.00 |