POU6F2 Antibody (F-7): sc-376709

POU6F2 Antibody (F-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects POU6F2 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-POU6F2 antibody (F-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. POU6F2, also known as RPF-1 (retina-derived POU domain factor 1), plays a crucial role in the differentiation of neuronal cells, particularly during the development of the central nervous system. This 683 amino acid nuclear protein is specifically expressed in the central nervous system, localizing to neurons in the dorsal hypothalamus and retinal cells, where POU6F2 acts as a transcription factor essential for the early differentiation of amacrine and ganglion cells. POU6F2 contains a homeobox DNA-binding domain and a POU-specific domain, and exists in two alternatively spliced isoforms. The gene encoding POU6F2 is located on human chromosome 7p14.1, and defects in POU6F2 have been linked to Wilms tumor 5 (WT5), highlighting its importance in both normal development and disease.

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POU6F2 Antibody (F-7) References:

1. The virtuoso of versatility: POU proteins that flex to fit.  |  Phillips, K. and Luisi, B. 2000. J Mol Biol. 302: 1023-39. PMID: 11183772
2. Refinement within single yeast artificial chromosome clones of a minimal region commonly deleted on the short arm of chromosome 7 in Wilms tumours.  |  Perotti, D., et al. 2001. Genes Chromosomes Cancer. 31: 42-7. PMID: 11284034
3. Germline mutations of the POU6F2 gene in Wilms tumors with loss of heterozygosity on chromosome 7p14.  |  Perotti, D., et al. 2004. Hum Mutat. 24: 400-7. PMID: 15459955
4. Wilms tumor in monozygous twins: clinical, pathological, cytogenetic and molecular case report.  |  Perotti, D., et al. 2005. J Pediatr Hematol Oncol. 27: 521-5. PMID: 16217254
5. Long noncoding RNA POU6F2-AS1 regulates lung cancer aggressiveness through sponging miR-34c-5p to modulate KCNJ4 expression.  |  Wu, XY., et al. 2021. Genet Mol Biol. 44: e20200050. PMID: 33999092
6. LncRNA POU6F2-AS2 contributes to malignant phenotypes and paclitaxel resistance by promoting SKP2 expression in stomach adenocarcinoma.  |  Jin, Y., et al. 2023. J Chemother. 35: 638-652. PMID: 36797828
7. POU6F2 mutation in humans with pubertal failure alters GnRH transcript expression.  |  Cho, HJ., et al. 2023. Front Endocrinol (Lausanne). 14: 1203542. PMID: 37600690
8. The m6A modification mediated-lncRNA POU6F2-AS1 reprograms fatty acid metabolism and facilitates the growth of colorectal cancer via upregulation of FASN.  |  Jiang, T., et al. 2024. Mol Cancer. 23: 55. PMID: 38491348
9. POU6F2, a risk factor for glaucoma, myopia and dyslexia, labels specific populations of retinal ganglion cells.  |  Lin, F., et al. 2024. Sci Rep. 14: 10096. PMID: 38698014
10. Retina-derived POU-domain factor-1: a complex POU-domain gene implicated in the development of retinal ganglion and amacrine cells.  |  Zhou, H., et al. 1996. J Neurosci. 16: 2261-74. PMID: 8601806

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-POU6F2 Antibody (F-7) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-POU6F2 Antibody (F-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

POU6F2 Antibody (F-7) Specifications

Alternate Product Name: POU6F2

Product Clone Name: F-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 9-153

Epitope Target: POU6F2

Epitope Species: human

Product Reactivity/Detection: POU6F2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for POU6F2 Antibody (F-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin