POU6F2 inhibitors belong to a specific chemical class characterized by their ability to selectively modulate the activity of the POU6F2 protein. POU6F2, or POU class 6 homeobox 2, is a transcription factor that plays a crucial role in the regulation of gene expression. Transcription factors are proteins that bind to DNA and influence the transcription of genetic information into RNA, thereby controlling the synthesis of proteins within a cell. POU6F2, in particular, is known to be involved in the developmental processes of various tissues and organs, making it an attractive target for pharmacological intervention.
The inhibitors designed to interact with POU6F2 are carefully crafted molecules that possess the ability to disrupt the normal functioning of this transcription factor. These compounds typically exhibit high specificity for POU6F2, selectively binding to its active site or regulatory regions, and thereby modulating its transcriptional activity. The intricate molecular interactions between POU6F2 inhibitors and the target protein may involve hydrogen bonding, hydrophobic interactions, or other specific binding motifs. By altering the function of POU6F2, these inhibitors influence downstream gene expression patterns, opening avenues for research into the fundamental biological processes governed by POU6F2. The development and study of POU6F2 inhibitors contribute to our understanding of gene regulation mechanisms, paving the way for advancements in basic biological research and providing valuable insights into the intricacies of cellular development and differentiation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
Binds to BET bromodomains, potentially disrupting protein-protein interactions involving POU6F2. | ||||||
I-BET 151 Hydrochloride | 1300031-49-5 (non HCl Salt) | sc-391115 | 10 mg | $450.00 | 2 | |
Targets BET bromodomains, possibly altering chromatin state and transcription factor activity. | ||||||
4-[(1E)-2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-2-pyridinylbenzenesulfonamide | 1395084-25-9 | sc-480120 | 5 mg | $300.00 | ||
Inhibits BRD4, a BET family member, which may affect transcription factors like POU6F2. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
HDAC inhibitor, can change chromatin structure potentially affecting POU6F2-mediated transcription. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
HDAC inhibitor, alters histone acetylation, possibly influencing POU6F2 activity. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
DNA methyltransferase inhibitor, could alter gene expression profiles relevant to POU6F2. | ||||||
SGC-CBP30 | 1613695-14-9 | sc-473871 sc-473871A | 5 mg 10 mg | $178.00 $338.00 | ||
CBP/p300 inhibitor, may disrupt transcription factor complexes involving POU6F2. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Inhibits multiple transcription factors, could affect POU6F2 by altering transcriptional networks. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Aldehyde dehydrogenase inhibitor, indirectly may affect transcription factor function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Inhibits various transcription factors, could disrupt POU6F2 pathways. | ||||||