PON3 Antibody (F-8): sc-515603

PON3 Antibody (F-8) is a mouse monoclonal IgM antibody that detects PON3 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-PON3 antibody (F-8) is available as the non-conjugated form. PON3 plays a crucial role in the detoxification of organophosphates, such as paroxon, which is a toxic metabolite of the insecticide parathion. By hydrolyzing paroxon, PON3 helps to mitigate the harmful effects of these compounds, making PON3 essential for protecting cells from oxidative stress and maintaining lipid metabolism. PON3 is primarily associated with high-density lipoproteins in serum, which are vital for cholesterol transport and cardiovascular health. The genes encoding PON1, PON2, and PON3 are closely linked on human chromosome 7q21.3, highlighting their evolutionary relationship and shared functional roles in lipid metabolism and detoxification processes. PON3 (F-8) antibody is an invaluable tool for researchers studying the biochemical pathways involving organophosphate metabolism and the protective mechanisms of high-density lipoproteins in various species.

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PON3 Antibody (F-8) References:

1. Rabbit serum paraoxonase 3 (PON3) is a high density lipoprotein-associated lactonase and protects low density lipoprotein against oxidation.  |  Draganov, DI., et al. 2000. J Biol Chem. 275: 33435-42. PMID: 10931838
2. A preliminary genetic interpretation of the esterase isozymes of human tissues.  |  Coates, PM., et al. 1975. Ann Hum Genet. 39: 1-20. PMID: 1180483
3. The molecular basis of the human serum paraoxonase activity polymorphism.  |  Humbert, R., et al. 1993. Nat Genet. 3: 73-6. PMID: 8098250
4. The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family.  |  Primo-Parmo, SL., et al. 1996. Genomics. 33: 498-507. PMID: 8661009
5. Human PON2 gene at 7q21.3: cloning, multiple mRNA forms, and missense polymorphisms in the coding sequence.  |  Mochizuki, H., et al. 1998. Gene. 213: 149-57. PMID: 9714608

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PON3 Antibody (F-8) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-PON3 Antibody (F-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PON3 Antibody (F-8) Specifications

Alternate Product Name: PON3

Product Clone Name: F-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 10-35

Epitope Target: PON3

Epitope Species: human

Product Reactivity/Detection: PON3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for PON3 Antibody (F-8): P: Blocking Peptide