

POLA2 Antibody (2759C3a) is a mouse monoclonal IgG2b antibody that detects POLA2 in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). POLA2, also known as DNA polymerase subunit alpha B, is a crucial 598 amino acid component of the DNA polymerase alpha enzyme complex, which is vital for DNA replication. POLA2 plays a significant role in the early stages of chromosomal DNA replication by linking the primase/polymerase complex to the replication machinery, ensuring accurate and efficient DNA synthesis. POLA2 is primarily localized in the nucleus, where POLA2 is essential for maintaining genomic stability. Notably, POLA2 can undergo post-translational modifications, such as phosphorylation, particularly during the G2/M phase of the cell cycle, which may influence activity and interactions with other proteins involved in DNA replication and repair. POLA2′s ability to interact with various proteins within the replication machinery underscores its importance in cellular processes, making anti-POLA2 antibody (2759C3a) an invaluable tool for researchers studying DNA replication dynamics and related pathways.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
POLA2 Antibody (2759C3a) | sc-81568 | 100 µg/ml | $339.00 |