PNUTS Antibody (47): sc-136044
- PNUTS Antibody (47) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against amino acids 605-716 of PNUTS of rat origin
- recommended for detection of PNUTS of mouse, rat and human origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PNUTS Antibody (47). This work is in progress.
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PNUTS Antibody (47) is a mouse monoclonal IgG1 antibody that detects PNUTS in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). PNUTS, also known as CAT53 or FB19, is encoded by the gene PPP1R10 and plays a crucial role in regulating the activity of serine/threonine protein phosphatases, particularly inhibiting the phosphatase activity of PP1α and PP1γ. This regulation is vital for maintaining cellular functions such as division, homeostasis, and apoptosis, as improper phosphatase activity can lead to various diseases, including cancer. PNUTS is primarily localized in the nucleus, where it is found in nucleoplasmic bodies and nucleoli, highlighting its importance in nuclear processes. The expression of PNUTS is notably high in tissues such as the brain, heart, lung, placenta, liver, kidney, pancreas, and skeletal muscle, indicating its potential involvement in diverse physiological functions across different organ systems. Anti-PNUTS antibody (47) is an essential tool for researchers studying the intricate mechanisms of protein phosphatase regulation and its implications in health and disease.
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PNUTS Antibody (47) References:
- PNUTS enhances in vitro chromosome decondensation in a PP1-dependent manner. | Landsverk, HB., et al. 2005. Biochem J. 390: 709-17. PMID: 15907195
- A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression. | Grelet, S., et al. 2017. Nat Cell Biol. 19: 1105-1115. PMID: 28825698
- PNUTS at the crossroads of tumorigenesis and metastasis formation. | Kiweler, N. and Krämer, OH. 2018. J Thorac Dis. 10: 560-563. PMID: 29607112
- WDR82/PNUTS-PP1 Prevents Transcription-Replication Conflicts by Promoting RNA Polymerase II Degradation on Chromatin. | Landsverk, HB., et al. 2020. Cell Rep. 33: 108469. PMID: 33264625
- Alternatively-spliced lncRNA-PNUTS promotes HCC cell EMT via regulating ZEB1 expression. | Zhao, H., et al. 2023. Tumori. 109: 28-37. PMID: 35139713
- The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase. | Wei, Y., et al. 2022. Nucleic Acids Res. 50: 3505-3522. PMID: 35244724
- The PNUTS-PP1 complex acts as an intrinsic barrier to herpesvirus KSHV gene expression and replication. | Devlin, AM., et al. 2022. Nat Commun. 13: 7447. PMID: 36460671
- A restrictor complex of ZC3H4, WDR82, and ARS2 integrates with PNUTS to control unproductive transcription. | Estell, C., et al. 2023. Mol Cell. 83: 2222-2239.e5. PMID: 37329883
- Restrictor synergizes with Symplekin and PNUTS to terminate extragenic transcription. | Russo, M., et al. 2023. Genes Dev. 37: 1017-1040. PMID: 38092518
- Aging-regulated PNUTS maintains endothelial barrier function via SEMA3B suppression. | Lozano-Vidal, N., et al. 2024. Commun Biol. 7: 541. PMID: 38714838
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PNUTS Antibody (47) | sc-136044 | 50 µg/0.5 ml | $322.00 |