PNK Antibody (C-11): sc-166080
- PNK Antibody (C-11) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 222-521 mapping at the C-terminus of PNK of human origin
- recommended for detection of PNK of human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-166080 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for PNK Antibody (C-11) for WB applications. These reagents are now offered in bundles with PNK Antibody (C-11) (see ordering information below).
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SEE ALSO...
PNK Antibody (C-11) is a mouse monoclonal IgG1 antibody that detects polynucleotide kinase (PNK) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PNK is a crucial nuclear protein encoded by the PNKP gene, playing a vital role in DNA repair mechanisms, particularly in response to damage from radiation or oxidative stress. Anti-PNK antibody (C-11) possesses both 3′-phosphatase and kinase activities, allowing PNK to catalyze the phosphorylation of DNA at hydroxy termini while also dephosphorylating 3′-phosphate termini, which is essential for maintaining genomic integrity. PNK facilitates the repair of damaged DNA, underscoring PNK′s importance in cellular survival and function, particularly in tissues with high turnover rates such as the testis, pancreas, spleen, kidney, and heart, where PNK is expressed at elevated levels. PNK monoclonal antibody (C-11) serves as an invaluable tool for researchers studying DNA repair pathways and the cellular response to genotoxic stress, providing insights into the mechanisms that protect against genomic instability and related diseases.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PNK Antibody (C-11) | sc-166080 | 200 µg/ml | $322.00 | |||
PNK Antibody (C-11): m-IgG Fc BP-HRP Bundle | sc-540007 | 200 µg Ab; 10 µg BP | $361.00 | |||
PNK Antibody (C-11): m-IgG1 BP-HRP Bundle | sc-541841 | 200 µg Ab; 20 µg BP | $361.00 | |||
PNK Antibody (C-11) X | sc-166080 X | 200 µg/0.1 ml | $322.00 |