PMS1 Antibody (E-3): sc-515302

PMS1 Antibody (E-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects PMS1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PMS1 (E-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. PMS1 protein plays a crucial role in the DNA mismatch repair pathway, which is essential for maintaining genomic stability by correcting errors that occur during DNA replication. This function is particularly important because defects in the mismatch repair system can lead to an increased risk of various cancers, including hereditary nonpolyposis colorectal cancer (HNPCC) and other malignancies characterized by microsatellite instability. The identification of PMS1 and its homolog PMS2 as key players in this pathway has underscored the significance of understanding their interactions and mutations, as they can provide insights into cancer development and potential therapeutic targets. PMS1 (E-3) antibody enables researchers to contribute to the growing body of knowledge surrounding DNA repair mechanisms and their implications in cancer biology.

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PMS1 Antibody (E-3) References:

1. Four linked genes participate in controlling sporulation efficiency in budding yeast.  |  Ben-Ari, G., et al. 2006. PLoS Genet. 2: e195. PMID: 17112318
2. Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.  |  Cannavo, E., et al. 2007. J Biol Chem. 282: 2976-86. PMID: 17148452
3. MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeast.  |  Prolla, TA., et al. 1994. Science. 265: 1091-3. PMID: 8066446
4. Mutations of two PMS homologues in hereditary nonpolyposis colon cancer.  |  Nicolaides, NC., et al. 1994. Nature. 371: 75-80. PMID: 8072530
5. Mismatch repair and cancer.  |  Palombo, F., et al. 1994. Nature. 367: 417. PMID: 8107798
6. Mutation of a mutL homolog in hereditary colon cancer.  |  Papadopoulos, N., et al. 1994. Science. 263: 1625-9. PMID: 8128251
7. Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer.  |  Bronner, CE., et al. 1994. Nature. 368: 258-61. PMID: 8145827
8. Genetic mapping of a locus predisposing to human colorectal cancer.  |  Peltomäki, P., et al. 1993. Science. 260: 810-2. PMID: 8484120
9. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis.  |  Ionov, Y., et al. 1993. Nature. 363: 558-61. PMID: 8505985

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PMS1 Antibody (E-3) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-PMS1 Antibody (E-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PMS1 Antibody (E-3) Specifications

Alternate Product Name: PMS1

Product Clone Name: E-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 633-932

Epitope Target: PMS1

Epitope Species: human

Product Reactivity/Detection: PMS1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for PMS1 Antibody (E-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin