PMPCA Antibody (G-2): sc-390470
- PMPCA Antibody (G-2) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 215-229 within an internal region of PMPCA of human origin
- recommended for detection of PMPCA of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for PMPCA Antibody (G-2) for WB applications. These reagents are now offered in bundles with PMPCA Antibody (G-2) (see ordering information below).
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PMPCA Antibody (G-2) is a mouse monoclonal IgG1 antibody that detects PMPCA (peptidase (mitochondrial processing) alpha) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PMPCA is a 525 amino acid protein belonging to the peptidase M16 family and functions as a crucial component in the mitochondrial matrix, where PMPCA plays a vital role in processing mitochondrial protein precursors by cleaving their transit peptides. This function is essential for the proper import and maturation of proteins necessary for mitochondrial function, which is critical for energy production and cellular metabolism. PMPCA′s importance is underscored by involvement in various cellular processes, and dysfunction can lead to mitochondrial-related diseases. Encoded by a gene located on human chromosome 9, PMPCA is part of a genomic region associated with several hereditary conditions, including hereditary hemorrhagic telangiectasia and Familial dysautonomia, highlighting the significance of PMPCA in both health and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PMPCA Antibody (G-2) | sc-390470 | 200 µg/ml | $316.00 | |||
PMPCA Antibody (G-2): m-IgG Fc BP-HRP Bundle | sc-540805 | 200 µg Ab; 10 µg BP | $354.00 | |||
PMPCA Antibody (G-2): m-IgG1 BP-HRP Bundle | sc-542380 | 200 µg Ab; 20 µg BP | $354.00 | |||
PMPCA (G-2) Neutralizing Peptide | sc-390470 P | 100 µg/0.5 ml | $68.00 |