PMPCA Antibody (B-8): sc-390471
- PMPCA Antibody (B-8) is a mouse monoclonal IgG2b κ PMPCA antibody, cited in 4 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 215-229 within an internal region of PMPCA of human origin
- PMPCA Antibody (B-8) is recommended for detection of PMPCA of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including canine
- Anti-PMPCA Antibody (B-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PMPCA Antibody (B-8) for WB and IHC(P) applications. These reagents are now offered in bundles with PMPCA Antibody (B-8) (see ordering information below).
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PMPCA Antibody (B-8) is a mouse monoclonal IgG2b kappa light chain antibody that detects PMPCA of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-PMPCA antibody (B-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PMPCA, also known as peptidase (mitochondrial processing) alpha, alpha-MPP, P-55, INPP5E, or MPPA, is a 525 amino acid protein that plays a crucial role in mitochondrial function by cleaving transit peptides from mitochondrial protein precursors, which is essential for proper import and processing of proteins into mitochondria. This process is vital for maintaining mitochondrial integrity and function, as PMPCA ensures proteins are correctly localized and activated within the organelle, thereby supporting cellular energy metabolism and apoptosis regulation. PMPCA is encoded by a gene located on human chromosome 9, a region associated with various genetic disorders, including hereditary hemorrhagic telangiectasia and familial dysautonomia, highlighting PMPCA′s importance in human health.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PMPCA Antibody (B-8) References:
- Lupus-like disease and high interferon levels corresponding to trisomy of the type I interferon cluster on chromosome 9p. | Zhuang, H., et al. 2006. Arthritis Rheum. 54: 1573-9. PMID: 16645992
- Pulmonary vascular manifestations of hereditary hemorrhagic telangiectasia (rendu-osler disease). | Cottin, V., et al. 2007. Respiration. 74: 361-78. PMID: 17641482
- Atypical BCR-ABL mRNA transcripts in adult acute lymphoblastic leukemia. | Burmeister, T., et al. 2007. Haematologica. 92: 1699-702. PMID: 18055996
- Organization of the amplified type I interferon gene cluster and associated chromosome regions in the interphase nucleus of human osteosarcoma cells. | Zeitz, MJ., et al. 2009. Chromosome Res. 17: 305-19. PMID: 19283497
- Neuroimaging supports central pathology in familial dysautonomia. | Axelrod, FB., et al. 2010. J Neurol. 257: 198-206. PMID: 19705052
- Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. | Nagase, T., et al. 1995. DNA Res. 2: 37-43. PMID: 7788527
- Functional cooperation of the mitochondrial processing peptidase subunits. | Luciano, P., et al. 1997. J Mol Biol. 272: 213-25. PMID: 9299349
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PMPCA Antibody (B-8) | sc-390471 | 200 µg/ml | $322.00 | |||
PMPCA Antibody (B-8): m-IgGκ BP-HRP Bundle | sc-523545 | 200 µg Ab, 40 µg BP | $361.00 | |||
PMPCA Antibody (B-8): m-IgG2b BP-HRP Bundle | sc-549125 | 200 µg Ab; 10 µg BP | $361.00 | |||
PMPCA Antibody (B-8) AC | sc-390471 AC | 500 µg/ml, 25% agarose | $424.00 | |||
PMPCA Antibody (B-8) HRP | sc-390471 HRP | 200 µg/ml | $322.00 | |||
PMPCA Antibody (B-8) FITC | sc-390471 FITC | 200 µg/ml | $336.00 | |||
PMPCA Antibody (B-8) PE | sc-390471 PE | 200 µg/ml | $349.00 | |||
PMPCA Antibody (B-8) Alexa Fluor® 488 | sc-390471 AF488 | 200 µg/ml | $364.00 | |||
PMPCA Antibody (B-8) Alexa Fluor® 546 | sc-390471 AF546 | 200 µg/ml | $364.00 | |||
PMPCA Antibody (B-8) Alexa Fluor® 594 | sc-390471 AF594 | 200 µg/ml | $364.00 | |||
PMPCA Antibody (B-8) Alexa Fluor® 647 | sc-390471 AF647 | 200 µg/ml | $364.00 | |||
PMPCA Antibody (B-8) Alexa Fluor® 680 | sc-390471 AF680 | 200 µg/ml | $364.00 | |||
PMPCA Antibody (B-8) Alexa Fluor® 790 | sc-390471 AF790 | 200 µg/ml | $364.00 | |||
PMPCA (B-8) Neutralizing Peptide | sc-390471 P | 100 µg/0.5 ml | $69.00 |