PML Antibody (C-5): sc-377303
- PML Antibody (C-5) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 157-394 of PML of human origin
- recommended for detection of all isoforms of PML of human origin by WB, IP, IF, IHC(P) and ELISA
- TransCruz reagent for ChIP application (sc-377303 X, 200 µg/0.1 ml)
- See PML (E-11): sc-377390 for PML antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgGκ BP-HRP is the preferred secondary detection reagent for PML Antibody (C-5) for WB and IHC(P) applications. This reagent is now offered in a bundle with PML Antibody (C-5) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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SEE ALSO...
PML Antibody (C-5) is a mouse monoclonal IgG2b antibody that detects PML in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). PML, or promyelocytic leukemia protein, functions as a crucial zinc finger transcription factor that plays a significant role in regulating gene expression and cellular differentiation. PML (C-5) antibody′s importance is underscored by PML′s involvement in the pathogenesis of acute promyelocytic leukemia, where the PML/RARα chimeric protein, resulting from a chromosomal translocation, disrupts normal myeloid differentiation and promotes oncogenesis. PML is primarily located in the nucleus, where PML forms nuclear bodies that are essential for various cellular processes, including apoptosis and DNA repair. PML′s presence in these nuclear structures is vital for maintaining genomic stability and regulating the cell cycle, making PML a key player in tumor suppression. Anti-PML antibody (C-5) enables researchers to gain insights into the molecular mechanisms underlying PML′s role in cancer biology and potential as a therapeutic target.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PML Antibody (C-5) | sc-377303 | 200 µg/ml | $322.00 | |||
PML Antibody (C-5): m-IgGκ BP-HRP Bundle | sc-535558 | 200 µg Ab; 40 µg BP | $361.00 | |||
PML Antibody (C-5) X | sc-377303 X | 200 µg/0.1 ml | $322.00 |