PMCA1/4 Antibody (6D131): sc-71907
- PMCA1/4 Antibody (6D131) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- epitope mapping to amino acids 719-738 of PMCA1/4 of human origin
- recommended for detection of PMCA1b, PMCA4a and PMCA4b of mouse, rat, human and Arabadopsis origin by WB, IP, IF and IHC(P); also reactive with additional species, including and bovine, feline and canine
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for PMCA1/4 Antibody (6D131) for WB and IHC(P) applications. These reagents are now offered in bundles with PMCA1/4 Antibody (6D131) (see ordering information below).
PMCA1/4 Antibody (6D131) is a mouse monoclonal IgG2a antibody that detects PMCA1/4 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. PMCA1/4 plays a crucial role in cellular calcium homeostasis, which is vital for various physiological processes, including muscle contraction, neurotransmitter release, and cell signaling. PMCA1/4 is primarily located in the plasma membrane, where PMCA1/4 functions to extrude calcium ions from the cell, thereby maintaining low intracellular calcium levels. This is particularly important in excitable cells, such as neurons and muscle cells, where calcium signaling is essential for proper function. Notably, PMCA4b, one of the isoforms, is predominantly expressed in developing mammary tissue and undergoes significant changes in expression during lactation, highlighting PMCA4b′s dynamic role in calcium regulation during critical physiological states. Additionally, PMCA4b is subject to post-translational modification, specifically cleavage by caspase-3, which produces an active fragment that responds more rapidly to calcium fluctuations than its autoinhibited counterpart. This unique regulatory mechanism underscores PMCA1/4′s importance in both normal cellular function and in the context of apoptosis, making anti-PMCA1/4 antibody (6D131) an essential tool for researchers studying calcium signaling and its implications in health and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PMCA1/4 Antibody (6D131) | sc-71907 | 200 µg/ml | $316.00 | |||
PMCA1/4 Antibody (6D131): m-IgG Fc BP-HRP Bundle | sc-539421 | 200 µg Ab; 10 µg BP | $354.00 | |||
PMCA1/4 Antibody (6D131): m-IgG2a BP-HRP Bundle | sc-546701 | 200 µg Ab; 10 µg BP | $354.00 |