plexin-B1 Antibody (A-8): sc-28372
- plexin-B1 Antibody (A-8) is a mouse monoclonal IgG2b κ plexin-B1 antibody, cited in 24 publications, provided at 200 µg/ml
- raised against amino acids 771-1070 of plexin-B1 of human origin
- plexin-B1 Antibody (A-8) is recommended for detection of plexin-B1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-plexin-B1 Antibody (A-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for plexin-B1 Antibody (A-8) for WB and IHC(P) applications. These reagents are now offered in bundles with plexin-B1 Antibody (A-8) (see ordering information below).
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plexin-B1 Antibody (A-8) is a mouse monoclonal IgG2b kappa light chain antibody that detects plexin-B1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-plexin-B1 antibody (A-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. plexin-B1 plays a crucial role in cellular signaling pathways, particularly in neuronal development and guidance, serving as a receptor for semaphorins, which regulate cell movement and positioning during embryogenesis and tissue remodeling. plexin-B1′s interaction with semaphorins guides axon development and establishes neural networks, making plexin-B1 essential for normal nervous system function. plexin-B1 also influences immune responses and cancer progression, highlighting plexin-B1′s significance in both health and disease. Understanding plexin-B1′s function and signaling mechanisms can provide insights into therapeutic targets for neurological disorders and cancer treatment.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
plexin-B1 Antibody (A-8) References:
- Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors. | Takahashi, T., et al. 1999. Cell. 99: 59-69. PMID: 10520994
- Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. | Tamagnone, L., et al. 1999. Cell. 99: 71-80. PMID: 10520995
- Analysis of the interaction of Plexin-B1 and Plexin-B2 with Rnd family proteins. | Wylie, T., et al. 2017. PLoS One. 12: e0185899. PMID: 29040270
- Plexin-B1 Mutation Drives Metastasis in Prostate Cancer Mouse Models. | Shorning, B., et al. 2023. Cancer Res Commun. 3: 444-458. PMID: 36936664
- Nanobody inhibitors of Plexin-B1 identify allostery in plexin-semaphorin interactions and signaling. | Cowan, R., et al. 2023. J Biol Chem. 299: 104740. PMID: 37088134
- Plexin-B1 and Plexin-B2 play non-redundant roles in GABAergic synapse formation. | Adel, SS., et al. 2024. Mol Cell Neurosci. 128: 103920. PMID: 38331011
- Regulation of cell distancing in peri-plaque glial nets by Plexin-B1 affects glial activation and amyloid compaction in Alzheimer's disease. | Huang, Y., et al. 2024. Nat Neurosci. 27: 1489-1504. PMID: 38802590
- The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules. | Kolodkin, AL., et al. 1993. Cell. 75: 1389-99. PMID: 8269517
- Identification of plexin family molecules in mice. | Kameyama, T., et al. 1996. Biochem Biophys Res Commun. 226: 396-402. PMID: 8806646
- Control of invasive growth by hepatocyte growth factor (HGF) and related scatter factors. | Tamagnone, L. and Comoglio, PM. 1997. Cytokine Growth Factor Rev. 8: 129-42. PMID: 9244408
- Plexin A is a neuronal semaphorin receptor that controls axon guidance. | Winberg, ML., et al. 1998. Cell. 95: 903-16. PMID: 9875845
- Plexins, semaphorins, and scatter factor receptors: a common root for cell guidance signals? | Artigiani, S., et al. 1999. IUBMB Life. 48: 477-82. PMID: 10637762
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
plexin-B1 Antibody (A-8) | sc-28372 | 200 µg/ml | $322.00 | |||
plexin-B1 Antibody (A-8): m-IgGκ BP-HRP Bundle | sc-520813 | 200 µg Ab, 40 µg BP | $361.00 | |||
plexin-B1 Antibody (A-8): m-IgG2b BP-HRP Bundle | sc-548854 | 200 µg Ab; 10 µg BP | $361.00 | |||
plexin-B1 Antibody (A-8) AC | sc-28372 AC | 500 µg/ml, 25% agarose | $424.00 | |||
plexin-B1 Antibody (A-8) HRP | sc-28372 HRP | 200 µg/ml | $322.00 | |||
plexin-B1 Antibody (A-8) FITC | sc-28372 FITC | 200 µg/ml | $336.00 | |||
plexin-B1 Antibody (A-8) PE | sc-28372 PE | 200 µg/ml | $349.00 | |||
plexin-B1 Antibody (A-8) Alexa Fluor® 488 | sc-28372 AF488 | 200 µg/ml | $364.00 | |||
plexin-B1 Antibody (A-8) Alexa Fluor® 546 | sc-28372 AF546 | 200 µg/ml | $364.00 | |||
plexin-B1 Antibody (A-8) Alexa Fluor® 594 | sc-28372 AF594 | 200 µg/ml | $364.00 | |||
plexin-B1 Antibody (A-8) Alexa Fluor® 647 | sc-28372 AF647 | 200 µg/ml | $364.00 | |||
plexin-B1 Antibody (A-8) Alexa Fluor® 680 | sc-28372 AF680 | 200 µg/ml | $364.00 | |||
plexin-B1 Antibody (A-8) Alexa Fluor® 790 | sc-28372 AF790 | 200 µg/ml | $364.00 |