PLC-XD1 Antibody (A-1): sc-393244

PLC-XD1 Antibody (A-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects PLC-XD1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PLC-XD1 (A-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PLC-XD1, also known as phosphatidylinositol-specific phospholipase C X domain-containing protein 1, is a 323 amino acid enzyme characterized by its phospholipase C X domain, which is crucial for catalytic activity in hydrolyzing phosphatidylinositol 4,5-bisphosphate to generate inositol trisphosphate and diacylglycerol, two important second messengers in cellular signaling pathways. Proper functioning of PLC-XD1 is vital for various physiological processes, including cell proliferation, differentiation, and apoptosis, making PLC-XD1 a significant player in both normal cellular functions and disease states. PLC-XD1 is encoded by a gene located in the pseudoautosomal region 1 (PAR1) of the X and Y chromosomes, suggesting inheritance as an autosomal gene rather than in a sex-linked manner. Disruptions in recombination processes within these regions can lead to male infertility and certain aneuploidy conditions, highlighting PLC-XD1′s importance in reproductive health. Active genes in PAR1 that escape X inactivation indicate a complex evolutionary history, as these regions are remnants of the ancestral Y chromosome, further emphasizing PLC-XD1′s biological significance in both health and disease.

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PLC-XD1 Antibody (A-1) References:

1. Complex events in the evolution of the human pseudoautosomal region 2 (PAR2).  |  Charchar, FJ., et al. 2003. Genome Res. 13: 281-6. PMID: 12566406
2. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.  |  Skaletsky, H., et al. 2003. Nature. 423: 825-37. PMID: 12815422
3. The human pseudoautosomal regions: a review for genetic epidemiologists.  |  Flaquer, A., et al. 2008. Eur J Hum Genet. 16: 771-9. PMID: 18398439
4. 'Micro-deletions' of the human Y chromosome and their relationship with male infertility.  |  Li, Z., et al. 2008. J Genet Genomics. 35: 193-9. PMID: 18439975
5. Recurrent loss of the Y chromosome and homozygous deletions within the pseudoautosomal region 1: association with male predominance in mantle cell lymphoma.  |  Nieländer, I., et al. 2008. Haematologica. 93: 949-50. PMID: 18515880
6. Multiple roles of phosphoinositide-specific phospholipase C isozymes.  |  Suh, PG., et al. 2008. BMB Rep. 41: 415-34. PMID: 18593525
7. The Human Pseudoautosomal Region (PAR): Origin, Function and Future.  |  Helena Mangs, A. and Morris, BJ. 2007. Curr Genomics. 8: 129-36. PMID: 18660847
8. Characterization of the bovine pseudoautosomal region and comparison with sheep, goat, and other mammalian pseudoautosomal regions.  |  Das, PJ., et al. 2009. Cytogenet Genome Res. 126: 139-47. PMID: 20016163
9. Use of integrative epigenetic and cytogenetic analyses to identify novel tumor-suppressor genes in malignant melanoma.  |  Mithani, SK., et al. 2011. Melanoma Res. 21: 298-307. PMID: 21606880
10. Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice.  |  Goldsworthy, M., et al. 2013. PLoS One. 8: e61870. PMID: 23826075
11. MicroRNA networks regulated by all-trans retinoic acid and Lapatinib control the growth, survival and motility of breast cancer cells.  |  Fisher, JN., et al. 2015. Oncotarget. 6: 13176-200. PMID: 25961594
12. The origin and evolution of the pseudoautosomal regions of human sex chromosomes.  |  Graves, JA., et al. 1998. Hum Mol Genet. 7: 1991-6. PMID: 9817914

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PLC-XD1 Antibody (A-1) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-PLC-XD1 Antibody (A-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PLC-XD1 Antibody (A-1) Specifications

Alternate Product Name: PLC-XD1

Product Clone Name: A-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 42-59

Epitope Target: PLC-XD1

Epitope Species: human

Product Reactivity/Detection: PLC-XD1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine and bovine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for PLC-XD1 Antibody (A-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin