plakophilin 3 Antibody (H-8): sc-515774

plakophilin 3 Antibody (H-8) is a mouse monoclonal IgG1 antibody that detects plakophilin 3 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Plakophilin 3 is a 797 amino acid protein characterized by eight arm-repeat domains and is a member of the beta-catenin family, playing a crucial role in cellular adhesion and signaling pathways. Plakophilin 3 is primarily localized to desmosomes, which are specialized cell-cell junctions that provide mechanical strength to tissues, particularly in stratified epithelia that experience significant mechanical stress. Plakophilin 3 in desmosomes is vital for maintaining tissue integrity and facilitating communication between cells, which is essential for proper tissue function and response to stress. Notably, plakophilin 3 has been implicated in lung carcinogenesis, with up-regulation serving as a frequent marker in lung cancer progression, highlighting potential as a prognostic indicator and therapeutic target. Anti-plakophilin 3 antibody (H-8) is an invaluable tool for researchers investigating plakophilin 3 in both normal physiology and disease states, particularly in cancer research.

The preferred plakophilin 3 antibody is plakophilin 3 Antibody (E-10): sc-166655.