plakophilin 3 Antibody (4A82): sc-71901

plakophilin 3 Antibody (4A82) is a mouse monoclonal IgG2b antibody that detects plakophilin 3 in mouse, rat, human, and canine samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Plakophilin 3 is a 797 amino acid protein characterized by eight arm-repeat domains and is a member of the beta-catenin family, playing a crucial role in cellular adhesion and signaling pathways. Plakophilin 3 is primarily localized to desmosomes, which are specialized cell-cell junctions that provide mechanical strength to tissues, particularly in stratified epithelia that experience significant mechanical stress. Plakophilin 3′s presence in desmosomes is vital for maintaining tissue integrity and facilitating communication between cells, which is essential for proper tissue function and response to stress. Notably, plakophilin 3 has been implicated in lung carcinogenesis, with up-regulation serving as a frequent marker in lung cancer, suggesting potential as a prognostic indicator and therapeutic target. Anti-plakophilin 3 antibody (4A82) serves as an invaluable tool for researchers investigating plakophilin 3′s roles in both normal physiology and disease states, particularly in cancer research.

The preferred plakophilin 3 antibody is plakophilin 3 Antibody (E-10): sc-166655.