plakophilin 2 Antibody (C-1): sc-393711

plakophilin 2 Antibody (C-1) is a mouse monoclonal IgG2a kappa light chain antibody that detects plakophilin 2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). plakophilin 2 Antibody (C-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. plakophilin 2 protein plays a crucial role in desmosome assembly, which is vital for maintaining the structural integrity of tissues subjected to mechanical stress, such as the heart and skin. By linking cadherins to the cytoskeletal intermediate filaments, plakophilin 2 contributes to cell adhesion and signaling pathways, ensuring proper cellular communication and tissue architecture. plakophilin 2′s importance is underscored by an essential role as a morphogenic factor in cardiac development, helping to regulate the formation and stability of desmosomes, thereby influencing heart function and overall tissue resilience. The plakophilin family, which includes plakophilins 1, 3, and 4, collectively influences cellular adhesion and signaling, making plakophilin 2 a key player in both developmental processes and the maintenance of tissue homeostasis.

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plakophilin 2 Antibody (C-1) References:

1. Desmosomal plakophilin 2 as a differentiation marker in normal and malignant tissues.  |  Mertens, C., et al. 1999. Differentiation. 64: 277-90. PMID: 10374264
2. Plakophilin-3, a novel armadillo-like protein present in nuclei and desmosomes of epithelial cells.  |  Bonné, S., et al. 1999. J Cell Sci. 112 (Pt 14): 2265-76. PMID: 10381383
3. The function of plakophilin 1 in desmosome assembly and actin filament organization.  |  Hatzfeld, M., et al. 2000. J Cell Biol. 149: 209-22. PMID: 10747098
4. Plakophilin 1 interferes with plakoglobin binding to desmoplakin, yet together with plakoglobin promotes clustering of desmosomal plaque complexes at cell-cell borders.  |  Bornslaeger, EA., et al. 2001. J Cell Sci. 114: 727-38. PMID: 11171378
5. Nuclear particles containing RNA polymerase III complexes associated with the junctional plaque protein plakophilin 2.  |  Mertens, C., et al. 2001. Proc Natl Acad Sci U S A. 98: 7795-800. PMID: 11416169
6. Protein binding and functional characterization of plakophilin 2. Evidence for its diverse roles in desmosomes and beta -catenin signaling.  |  Chen, X., et al. 2002. J Biol Chem. 277: 10512-22. PMID: 11790773
7. Defining desmosomal plakophilin-3 interactions.  |  Bonné, S., et al. 2003. J Cell Biol. 161: 403-16. PMID: 12707304
8. Lack of plakophilin 1 increases keratinocyte migration and reduces desmosome stability.  |  South, AP., et al. 2003. J Cell Sci. 116: 3303-14. PMID: 12840072
9. Plakophilin 1: an important stabilizer of desmosomes.  |  South, AP. 2004. Clin Exp Dermatol. 29: 161-7. PMID: 14987275
10. Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation.  |  Grossmann, KS., et al. 2004. J Cell Biol. 167: 149-60. PMID: 15479741
11. Impaired Plakophilin-2 in obesity breaks cell cycle dynamics to breed adipocyte senescence.  |  Lluch, A., et al. 2023. Nat Commun. 14: 5106. PMID: 37607954
12. Plakophilin 2 gene therapy prevents and rescues arrhythmogenic right ventricular cardiomyopathy in a mouse model harboring patient genetics.  |  Bradford, WH., et al. 2023. Nat Cardiovasc Res. 2: 1246-1261. PMID: 39196150

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-plakophilin 2 Antibody (C-1) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-plakophilin 2 Antibody (C-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

plakophilin 2 Antibody (C-1) Specifications

Alternate Product Name: plakophilin 2

Product Clone Name: C-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 757-881

Epitope Target: plakophilin 2

Epitope Species: human

Product Reactivity/Detection: plakophilin 2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for plakophilin 2 Antibody (C-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin