plakophilin 1 Antibody (3G250): sc-71900

plakophilin 1 Antibody (3G250) is a mouse monoclonal IgG1 antibody that detects plakophilin 1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Plakophilin 1 is a crucial component of desmosomes, which are specialized cell-cell junctions that provide mechanical strength to tissues, particularly in areas subjected to significant stress, such as the skin and heart. Plakophilin 1 plays a vital role in mediating increases in desmosomal protein content and facilitating desmosome assembly, which is essential for maintaining tissue integrity and proper cellular architecture. Additionally, plakophilin 1 is involved in regulating cell migration, a process that is critical during development and wound healing. Localization to both the nucleus and desmosomes underscores plakophilin 1′s multifunctional nature, allowing participation in both structural and signaling roles within the cell. Anti-plakophilin 1 antibody (3G250) is an invaluable tool for researchers studying the dynamics of desmosomal adhesion and the molecular mechanisms underlying tissue development and repair.

The preferred plakophilin 1 antibody is plakophilin 1 Antibody (10B2): sc-33636.