PLAA Antibody (E-1): sc-390454

PLAA Antibody (E-1) is a mouse monoclonal IgG2a kappa light chain antibody that detects PLAA protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-PLAA antibody (E-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PLAA protein, also known as phospholipase A-2-activating protein or DOA1, is a 795 amino acid protein characterized by one PFU domain, one PUL domain, and seven WD repeats. WD-repeat motifs, which are crucial for PLAA function, form a tertiary propeller structure that facilitates interactions with other proteins. These interactions support various cellular processes, including chromatin assembly, cell cycle regulation, signal transduction, RNA processing, apoptosis, and vesicular trafficking. PLAA plays a significant role in phospholipase A2 activation, which regulates inflammatory responses, making PLAA a key player in inflammatory disease pathophysiology.

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PLAA Antibody (E-1) References:

1. Cloning of the human phospholipase A2 activating protein (hPLAP) gene on the chromosome 9p21 melanoma deleted region.  |  Ruiz, A., et al. 1999. Gene. 239: 155-61. PMID: 10571045
2. Chromosomal localization of phospholipase A2 activating protein, an Ets2 target gene, to 9p21.  |  Beatty, BG., et al. 1999. Genomics. 62: 529-32. PMID: 10644453
3. Function assignment to conserved residues in mammalian alkaline phosphatases.  |  Kozlenkov, A., et al. 2002. J Biol Chem. 277: 22992-9. PMID: 11937510
4. Bimodal regulatory effect of melittin and phospholipase A2-activating protein on human type II secretory phospholipase A2.  |  Koumanov, K., et al. 2003. Cell Biol Int. 27: 871-7. PMID: 14499668
5. Phospholipase A2 activating protein (PLAA) is required for 1alpha,25(OH)2D3 signaling in growth plate chondrocytes.  |  Schwartz, Z., et al. 2005. J Cell Physiol. 203: 54-70. PMID: 15368540
6. Alteration in the activation state of new inflammation-associated targets by phospholipase A2-activating protein (PLAA).  |  Zhang, F., et al. 2008. Cell Signal. 20: 844-61. PMID: 18291623
7. Cloning of a phospholipase A2-activating protein.  |  Clark, MA., et al. 1991. Proc Natl Acad Sci U S A. 88: 5418-22. PMID: 2052621
8. Molecular characterization of cDNA for phospholipase A2-activating protein.  |  Chopra, AK., et al. 1999. Biochim Biophys Acta. 1444: 125-30. PMID: 9931468

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PLAA Antibody (E-1) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-PLAA Antibody (E-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PLAA Antibody (E-1) Specifications

Alternate Product Name: PLAA

Product Clone Name: E-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 496-795

Epitope Target: PLAA

Epitope Species: human

Product Reactivity/Detection: PLAA

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for PLAA Antibody (E-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin