PKR Antibody (A-12): sc-393038
- PKR Antibody (A-12) is a mouse monoclonal IgG2a κ, cited in 5 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2-27 at the N-terminus of PKR of human origin
- recommended for detection of PKR of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See PKR (B-10): sc-6282 for PKR antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PKR Antibody (A-12) for WB and IHC(P) applications. These reagents are now offered in bundles with PKR Antibody (A-12) (see ordering information below).
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PKR Antibody (A-12) is a mouse monoclonal IgG2a antibody that detects PKR in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). PKR, or interferon-inducible RNA-dependent protein serine/threonine kinase, plays a crucial role in the cellular response to viral infections by phosphorylating the α subunit of the protein synthesis initiation factor eIF-2. This phosphorylation event on serine-51 effectively inhibits translation, thereby limiting viral replication and promoting an antiviral state within the cell. PKR′s structure features distinct domains: serine/threonine kinase catalytic domains in the carboxy terminal half and RNA-binding domains in the amino terminal region. This structural organization allows PKR to effectively recognize and respond to double-stranded RNA, a common indicator of viral presence, highlighting PKR′s significance in innate immunity. Molecular cDNA clones of PKR have been isolated from both human and mouse cells, underscoring PKR′s evolutionary conservation and importance in immune responses. Anti-PKR antibody (A-12) serves as an essential tool for researchers studying viral infection mechanisms and protein synthesis regulation in response to stress signals.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PKR Antibody (A-12) | sc-393038 | 200 µg/ml | $316.00 | |||
PKR Antibody (A-12): m-IgG Fc BP-HRP Bundle | sc-538122 | 200 µg Ab; 10 µg BP | $354.00 | |||
PKR Antibody (A-12): m-IgGκ BP-HRP Bundle | sc-535677 | 200 µg Ab; 40 µg BP | $354.00 | |||
PKR Antibody (A-12): m-IgG2a BP-HRP Bundle | sc-548209 | 200 µg Ab; 10 µg BP | $354.00 | |||
PKR (A-12) Neutralizing Peptide | sc-393038 P | 100 µg/0.5 ml | $68.00 |