PKDCC Antibody (G-10): sc-514504

PKDCC Antibody (G-10) is a mouse monoclonal IgM antibody that detects PKDCC protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-PKDCC antibody (G-10) is available as the non-conjugated form. PKDCC protein, also known as protein kinase-like protein SgK493, sugen kinase 493, or vertebrate lonesome kinase, consists of 493 amino acids and belongs to the protein kinase superfamily. PKDCC (G-10) antibody targets a protein primarily located in the Golgi apparatus, where PKDCC plays a crucial role in protein transport to the plasma membrane, essential for maintaining cellular function and communication. PKDCC protein is involved in ATP binding, nucleotide binding, protein kinase activity, and transferase activity, all vital for various cellular processes, including regulation of chondrocyte differentiation necessary for longitudinal bone growth. PKDCC gene is conserved across several species, including chimpanzees, dogs, mice, rats, and zebrafish, and PKDCC protein is ubiquitously expressed in human tissues. While PKDCC has been suggested to be associated with atopy and asthma in atopic individuals, studies involving murine PKDCC knockouts reveal extreme phenotypes that don′t correlate with atopy or asthma, indicating a potential additional role in abnormal respiratory functions.

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PKDCC Antibody (G-10) References:

1. Genomic analysis of the eukaryotic protein kinase superfamily: a perspective.  |  Hanks, SK. 2003. Genome Biol. 4: 111. PMID: 12734000
2. Short limbs, cleft palate, and delayed formation of flat proliferative chondrocytes in mice with targeted disruption of a putative protein kinase gene, Pkdcc (AW548124).  |  Imuta, Y., et al. 2009. Dev Dyn. 238: 210-22. PMID: 19097194
3. Cyclical expression of the Notch/Wnt regulator Nrarp requires modulation by Dll3 in somitogenesis.  |  Sewell, W., et al. 2009. Dev Biol. 329: 400-9. PMID: 19268448
4. The novel protein kinase Vlk is essential for stromal function of mesenchymal cells.  |  Kinoshita, M., et al. 2009. Development. 136: 2069-79. PMID: 19465597
5. A pooling-based genome-wide analysis identifies new potential candidate genes for atopy in the European Community Respiratory Health Survey (ECRHS).  |  Castro-Giner, F., et al. 2009. BMC Med Genet. 10: 128. PMID: 19961619
6. Genome-wide association identifies a deletion in the 3' untranslated region of striatin in a canine model of arrhythmogenic right ventricular cardiomyopathy.  |  Meurs, KM., et al. 2010. Hum Genet. 128: 315-24. PMID: 20596727

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PKDCC Antibody (G-10) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-PKDCC Antibody (G-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PKDCC Antibody (G-10) Specifications

Alternate Product Name: PKDCC

Product Clone Name: G-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 210-232

Epitope Target: PKDCC

Epitope Species: human

Product Reactivity/Detection: PKDCC

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for PKDCC Antibody (G-10): P: Blocking Peptide