PISD Antibody (B-3): sc-515176

PISD Antibody (B-3) is a mouse monoclonal IgG2a antibody that detects phosphatidylserine decarboxylase (PISD) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PISD plays a crucial role in lipid metabolism by catalyzing the conversion of phosphatidylserine to phosphatidylethanolamine, a process essential for maintaining cellular membrane integrity and function. PISD is predominantly located in the inner mitochondrial membrane, where PISD contributes to the synthesis of phosphatidylethanolamine, a key component of mitochondrial membranes vital for proper mitochondrial function and energy production. PISD′s presence in the mitochondria underscores PISD′s importance in cellular respiration and apoptosis, as phosphatidylethanolamine is involved in the formation of membrane structures that facilitate these processes. PISD exists in two isoforms, PISD alpha and PISD beta, which arise from the cleavage of a conserved LGST motif, and PISD can form heterodimers, enhancing functional versatility. Highly expressed in liver and testis, PISD is encoded by a gene located on human chromosome 22q12.2, making PISD a significant target for studies related to metabolic disorders and mitochondrial dysfunction.

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PISD Antibody (B-3) References:

1. Sildenafil for psychotropic-induced sexual dysfunction in 31 women and 61 men.  |  Salerian, AJ., et al. 2000. J Sex Marital Ther. 26: 133-40. PMID: 10782445
2. A parallel and incremental algorithm for efficient unique signature discovery on DNA databases.  |  Lee, HP., et al. 2010. BMC Bioinformatics. 11: 132. PMID: 20230647
3. Identifying candidate genes involved in osteoarthritis through bioinformatics analysis.  |  Zhang, X., et al. 2016. Clin Exp Rheumatol. 34: 282-90. PMID: 26968041
4. Functional Isolation of Tumor-Initiating Cells using Microfluidic-Based Migration Identifies Phosphatidylserine Decarboxylase as a Key Regulator.  |  Chen, YC., et al. 2018. Sci Rep. 8: 244. PMID: 29321615
5. Forkhead-box series expression network is associated with outcome of clear-cell renal cell carcinoma.  |  Jia, Z., et al. 2018. Oncol Lett. 15: 8669-8680. PMID: 29805604
6. The Liberfarb syndrome, a multisystem disorder affecting eye, ear, bone, and brain development, is caused by a founder pathogenic variant in thePISD gene.  |  Peter, VG., et al. 2019. Genet Med. 21: 2734-2743. PMID: 31263216
7. Contrast-enhanced ultrasound imaging using pulse inversion spectral deconvolution.  |  Khairalseed, M., et al. 2019. J Acoust Soc Am. 146: 2466. PMID: 31671995
8. Proteomics reveals mitochondrial dysfunction and energy metabolism disturbance of intestine in a nonhuman primate model of depression.  |  Chen, X., et al. 2023. J Affect Disord. 333: 562-570. PMID: 37080496
9. Differential alternative polyadenylation response to high-fat diet between polygenic obese and healthy lean mice.  |  Mikec, Š., et al. 2023. Biochem Biophys Res Commun. 666: 83-91. PMID: 37178509
10. Integrative Placental Multi-Omics Analysis Reveals Perturbed Pathways and Potential Prognostic Biomarkers in Gestational Hypertension.  |  Varghese, B., et al. 2024. Arch Med Res. 55: 102909. PMID: 37984232

The preferred PISD antibody is PISD Antibody (H-2): sc-390070.