PINX1 Antibody (H-8): sc-376394
- PINX1 Antibody (H-8) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 8-29 at the N-terminus of PINX1 of human origin
- recommended for detection of PINX1 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG2b BP-HRP is the preferred secondary detection reagent for PINX1 Antibody (H-8) for WB applications. This reagent is now offered in a bundle with PINX1 Antibody (H-8) (see ordering information below).
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PINX1 Antibody (H-8) is a mouse monoclonal IgG2b light chain antibody that detects PINX1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PINX1, also known as LPTL or LPTS, is a crucial protein that plays a significant role in telomere regulation and acts as a tumor suppressor. PINX1 is predominantly localized in nucleoli and telomere speckles, where PINX1 contains a G-patch domain and a telomeric inhibiting domain (TID) at its C-terminus. The TID domain is particularly important as TID interacts specifically with the telomerase reverse transcriptase (TERT), inhibiting TERT activity and thereby regulating telomerase function. This inhibition is vital because overexpression of PINX1 can lead to shortened telomeres, which further supports PINX1′s role in controlling telomerase activity. Conversely, depletion of PINX1 significantly enhances telomerase activity, potentially contributing to the tumorigenicity of cancer cells. anti-PINX1 antibody (H-8) serves as an essential tool for studying the mechanisms of telomere maintenance and the implications of PINX1 in cancer biology, making anti-PINX1 antibody (H-8) invaluable for researchers investigating cell proliferation and tumor suppression.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PINX1 Antibody (H-8) | sc-376394 | 200 µg/ml | $322.00 | |||
PINX1 Antibody (H-8): m-IgG2b BP-HRP Bundle | sc-548596 | 200 µg Ab; 10 µg BP | $361.00 | |||
PINX1 (H-8) Neutralizing Peptide | sc-376394 P | 100 µg/0.5 ml | $69.00 |