PINX1 Antibody (A-9): sc-376588
- PINX1 Antibody (A-9) is a mouse monoclonal IgG1 provided at 200 µg/ml
- specific for an epitope mapping between amino acids 8-29 at the N-terminus of PINX1 of human origin
- recommended for detection of PINX1 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for PINX1 Antibody (A-9) for WB applications. These reagents are now offered in bundles with PINX1 Antibody (A-9) (see ordering information below).
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PINX1 (A-9) is a mouse monoclonal IgG1 antibody. PINX1 (PIN2/TRF1-interacting protein X1), also known as LPTL or LPTS (liver-related putative tumor suppressor), is a ubiquitously expressed protein that localizes to nucleoli and telomere speckles. PINX1 contains one G-patch domain and one telomeric inhibiting domain (TID) at its C-terminus. PINX1 interacts with the telomere protein TRF1 and the telomerase reverse transcriptase TERT. The TID domain of PINX1 specifically interacts with TERT and functions to inhibit its activity, thus participating in the regulation of telomerase activity. Overexpression of PINX1 leads to shortened telomeres, further supporting an inhibitory role of PINX1 on telomerase activity. The depletion of PINX1 significantly increases telomerase activity and may lead to tumorigenicity of cancer cells. This suggests that PINX1 acts as a tumor suppressor and can inhibit cell proliferation. In addition, PINX1 is involved in nucleolar RNA maturation.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PINX1 Antibody (A-9) | sc-376588 | 200 µg/ml | $322.00 | |||
PINX1 Antibody (A-9): m-IgG Fc BP-HRP Bundle | sc-540603 | 200 µg Ab; 10 µg BP | $361.00 | |||
PINX1 Antibody (A-9): m-IgG1 BP-HRP Bundle | sc-542237 | 200 µg Ab; 20 µg BP | $361.00 | |||
PINX1 (A-9) Neutralizing Peptide | sc-376588 P | 100 µg/0.5 ml | $69.00 |