PINX1 Antibody (A-8): sc-374114
- PINX1 Antibody (A-8) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against amino acids 1-150 mapping at the N-terminus of PINX1 of human origin
- recommended for detection of PINX1 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgGκ BP-HRP is the preferred secondary detection reagent for PINX1 Antibody (A-8) for WB applications. This reagent is now offered in a bundle with PINX1 Antibody (A-8) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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PINX1 Antibody (A-8) is a mouse monoclonal IgG2a light chain antibody that detects PINX1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PINX1, also known as LPTL or LPTS, is a crucial protein that plays a significant role in telomere regulation and tumor suppression. PINX1 is ubiquitously expressed and primarily localizes to nucleoli and telomere speckles, where PINX1 contains a G-patch domain and a telomeric inhibiting domain (TID) at its C-terminus. The TID domain specifically interacts with telomerase reverse transcriptase (TERT), inhibiting TERT activity and regulating telomerase function. This inhibition is vital because PINX1 overexpression can lead to shortened telomeres, which further supports PINX1′s role in controlling telomerase activity. Conversely, PINX1 depletion significantly enhances telomerase activity, potentially contributing to the tumorigenicity of cancer cells. PINX1 functions as a tumor suppressor that not only inhibits cell proliferation but is also involved in nucleolar RNA maturation, highlighting PINX1′s multifaceted role in cellular processes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PINX1 Antibody (A-8) | sc-374114 | 200 µg/ml | $322.00 | |||
PINX1 Antibody (A-8): m-IgGκ BP-HRP Bundle | sc-535387 | 200 µg Ab; 40 µg BP | $361.00 |