PINK1 Antibody (38CT20.8.5): sc-517353

PINK1 Antibody (38CT20.8.5) is a mouse monoclonal IgG1 kappa light chain antibody that detects PINK1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). anti-PINK1 antibody (38CT20.8.5) is available as a non-conjugated monoclonal isotype antibody. PINK1, or PTEN induced putative kinase 1, is a crucial member of the serine/threonine protein kinase family and functions as a tumor suppressor. PINK1 is primarily localized in mitochondria, where PINK1 plays a vital role in maintaining mitochondrial integrity and function. PINK1′s presence in mitochondria helps protect cells from mitochondrial dysfunction, particularly during cellular stress, by phosphorylating mitochondrial proteins essential for energy production and apoptosis regulation. Mutations in the PINK1 gene (PARK6) can lead to altered autophosphorylation activity, which is linked to early onset Parkinson′s disease, a neurodegenerative disorder characterized by motor symptoms such as resting tremor and rigidity. PINK1′s widespread expression in tissues such as testis, skeletal muscle, and heart underscores PINK1′s importance in various physiological processes, while lower expression in tissues like pancreas and brain highlights specialized roles in cellular health and disease.

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PINK1 Antibody (38CT20.8.5) References:

1. Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway.  |  Unoki, M. and Nakamura, Y. 2001. Oncogene. 20: 4457-65. PMID: 11494141
2. Hereditary early-onset Parkinson's disease caused by mutations in PINK1.  |  Valente, EM., et al. 2004. Science. 304: 1158-60. PMID: 15087508
3. The gene responsible for PARK6 Parkinson's disease, PINK1, does not influence common forms of parkinsonism.  |  Healy, DG., et al. 2004. Ann Neurol. 56: 329-35. PMID: 15349859
4. Novel PINK1 mutations in early-onset parkinsonism.  |  Hatano, Y., et al. 2004. Ann Neurol. 56: 424-7. PMID: 15349870
5. Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease.  |  Rogaeva, E., et al. 2004. Arch Neurol. 61: 1898-904. PMID: 15596610
6. Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism.  |  Silvestri, L., et al. 2005. Hum Mol Genet. 14: 3477-92. PMID: 16207731
7. Analysis of the PINK1 gene in a cohort of patients with sporadic early-onset parkinsonism in Taiwan.  |  Fung, HC., et al. 2006. Neurosci Lett. 394: 33-6. PMID: 16257123
8. Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission.  |  Dagda, RK., et al. 2009. J Biol Chem. 284: 13843-13855. PMID: 19279012
9. PINK1 phosphorylates Drp1S616 to regulate mitophagy-independent mitochondrial dynamics.  |  Han, H., et al. 2020. EMBO Rep. 21: e48686. PMID: 32484300
10. Targeting ATAD3A-PINK1-mitophagy axis overcomes chemoimmunotherapy resistance by redirecting PD-L1 to mitochondria.  |  Xie, XQ., et al. 2023. Cell Res. 33: 215-228. PMID: 36627348
11. Unconventional initiation of PINK1/Parkin mitophagy by Optineurin.  |  Nguyen, TN., et al. 2023. Mol Cell. 83: 1693-1709.e9. PMID: 37207627
12. PINK1 and Parkin regulate IP3R-mediated ER calcium release.  |  Ham, SJ., et al. 2023. Nat Commun. 14: 5202. PMID: 37626046

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PINK1 Antibody (38CT20.8.5) has 79 citations in a variety of scientific publications.

Primary antibodies like Anti-PINK1 Antibody (38CT20.8.5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PINK1 Antibody (38CT20.8.5) Specifications

Alternate Product Name: PINK1

Product Clone Name: 38CT20.8.5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: PINK1

Epitope Species: human

Product Reactivity/Detection: PINK1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 50 µg IgG₁ kappa light chain in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 79 citations in various scientific publications

Available Conjugates/Forms for PINK1 Antibody (38CT20.8.5): N/A

The preferred PINK1 antibody is PINK1 Antibody (C-3): sc-518052.