Pinch-1 Antibody (B-8): sc-393151
- Pinch-1 Antibody (B-8) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 12-41 near the N-terminus of Pinch-1 of human origin
- recommended for detection of Pinch-1 and Pinch-2 of mouse, rat and human origin, and Pinch-3 of human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine, porcine and avian
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Pinch-1 Antibody (B-8) for WB applications. These reagents are now offered in bundles with Pinch-1 Antibody (B-8) (see ordering information below).
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Pinch-1 Antibody (B-8) is a mouse monoclonal IgG1 antibody that detects Pinch-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Pinch-1 is a crucial focal adhesion protein that plays a significant role in the ILK-PINCH complex, which is integral to growth factor and integrin signaling pathways. This complex regulates cell differentiation, proliferation, and survival as an effector of integrin and growth factor signaling. Pinch-1 is predominantly located in the cytoplasm and expressed across various tissues, featuring a structure composed of five LIM domains, a nuclear localization signal, and a nuclear export signal. These LIM domains facilitate protein-protein interactions, allowing Pinch-1 to effectively mediate signaling pathways that influence cellular responses to external stimuli. The PINCH-1/ILK complex is modulated by PINCH-2, which also interacts with ILK, highlighting dynamic regulatory mechanisms that govern cellular functions. Anti-Pinch-1 antibody (B-8) serves as an essential tool for researchers investigating focal adhesion proteins in cellular signaling and their implications in various biological processes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pinch-1 Antibody (B-8) | sc-393151 | 200 µg/ml | $322.00 | |||
Pinch-1 Antibody (B-8): m-IgG Fc BP-HRP Bundle | sc-538155 | 200 µg Ab; 10 µg BP | $361.00 | |||
Pinch-1 Antibody (B-8): m-IgGκ BP-HRP Bundle | sc-535715 | 200 µg Ab; 40 µg BP | $361.00 | |||
Pinch-1 Antibody (B-8): m-IgG1 BP-HRP Bundle | sc-545551 | 200 µg Ab; 20 µg BP | $361.00 | |||
Pinch-1 (B-8) Neutralizing Peptide | sc-393151 P | 100 µg/0.5 ml | $69.00 |