Pim-2 Antibody (D-8): sc-271844
- Pim-2 Antibody (D-8) is a mouse monoclonal IgG2b κ, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 231-255 within an internal region of Pim-2 of human origin
- recommended for detection of Pim-2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine, bovine and porcine
- See Pim-2 (1D12): sc-13514 for Pim-2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Pim-2 Antibody (D-8) for WB applications. These reagents are now offered in bundles with Pim-2 Antibody (D-8) (see ordering information below).
Pim-2 Antibody (D-8) is a mouse monoclonal IgG2b antibody that detects Pim-2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Pim-2, a serine/threonine kinase encoded by the pim-2 gene, plays a crucial role in various cellular processes, including cell survival, proliferation, and differentiation, making Pim-2 a significant player in oncogenesis and hematopoietic development. Pim-2 is primarily located in the cytoplasm and nucleus of cells, indicating involvement in signaling pathways that regulate cell cycle progression and apoptosis. Pim-2′s presence in hematopoietic lineages and elevated expression in leukemic and lymphomic cells highlight anti-Pim-2 antibody (D-8)′s potential as a biomarker for cancer diagnosis and prognosis. Pim-2′s ability to autophosphorylate enhances kinase activity, thereby influencing downstream signaling cascades vital for maintaining cellular homeostasis and responding to stress. Pim-2 (D-8) antibody serves as an essential tool for researchers investigating this kinase in various biological contexts, particularly in studies related to memory formation and tumor biology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Pim-2 Antibody (D-8) References:
- Target integration by a chimeric Sp1 zinc finger domain-Moloney murine leukemia virus integrase in vivo. | Peng, WJ., et al. 2002. J Biomed Sci. 9: 171-84. PMID: 11914585
- Proviral integration site for Moloney murine leukemia virus 1, but not phosphatidylinositol-3 kinase, is essential in the antiapoptotic signaling cascade initiated by IL-5 in eosinophils. | Andina, N., et al. 2009. J Allergy Clin Immunol. 123: 603-11. PMID: 19152965
- International comparison of the performance of the paediatric index of mortality (PIM) 2 score in two national data sets. | Leteurtre, S., et al. 2012. Intensive Care Med. 38: 1372-80. PMID: 22569555
- Proviral integration site for Moloney murine leukemia virus (PIM) kinases promote human T helper 1 cell differentiation. | Tahvanainen, J., et al. 2013. J Biol Chem. 288: 3048-58. PMID: 23209281
- Pim-2/mTORC1 Pathway Shapes Inflammatory Capacity in Rheumatoid Arthritis Synovial Cells Exposed to Lipid Peroxidations. | Yin, G., et al. 2015. Biomed Res Int. 2015: 240210. PMID: 26064888
- Ubiquitin-specific protease 22 acts as an oncoprotein to maintain glioma malignancy through deubiquitinating B cell-specific Moloney murine leukemia virus integration site 1 for stabilization. | Qiu, GZ., et al. 2018. Cancer Sci. 109: 2199-2210. PMID: 29788550
- Expression of B Cell-Specific Moloney Murine Leukemia Virus Integration Site 1 (BMI-1) and WW Domain-Containing Oxidoreductase (WWOX) in Liver Cancer Tissue and Normal Liver Tissue. | Yu, J., et al. 2018. Med Sci Monit. 24: 6673-6679. PMID: 30242144
- Insights into the Interaction Mechanisms of the Proviral Integration Site of Moloney Murine Leukemia Virus (Pim) Kinases with Pan-Pim Inhibitors PIM447 and AZD1208: A Molecular Dynamics Simulation and MM/GBSA Calculation Study. | Chen, Q., et al. 2019. Int J Mol Sci. 20: PMID: 31671637
- Pim-2 Kinase Regulates Energy Metabolism in Multiple Myeloma. | Liu, Z., et al. 2022. Cancers (Basel). 15: PMID: 36612063
- Mutants and pseudorevertants of Moloney murine leukemia virus with alterations at the integration site. | Colicelli, J. and Goff, SP. 1985. Cell. 42: 573-80. PMID: 4028161
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pim-2 Antibody (D-8) | sc-271844 | 200 µg/ml | $316.00 | |||
Pim-2 Antibody (D-8): m-IgGκ BP-HRP Bundle | sc-535050 | 200 µg Ab; 40 µg BP | $354.00 | |||
Pim-2 Antibody (D-8): m-IgG2b BP-HRP Bundle | sc-549336 | 200 µg Ab; 10 µg BP | $354.00 | |||
Pim-2 (D-8) Neutralizing Peptide | sc-271844 P | 100 µg/0.5 ml | $68.00 |