PILR-α/β Antibody (H-2): sc-390847
- PILR-α/β Antibody (H-2) is a mouse monoclonal IgG2a κ PILR-α/β antibody provided at 200 µg/ml
- raised against amino acids 25-127 mapping near the N-terminus of PILR-β of mouse origin
- PILR- alpha / beta Antibody (H-2) is recommended for detection of PILR-α/β of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-PILR- alpha / beta Antibody (H-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PILR-α/β Antibody (H-2) for WB applications. These reagents are now offered in bundles with PILR-α/β Antibody (H-2) (see ordering information below).
PILR-α/β Antibody (H-2) is a mouse monoclonal IgG2a kappa light chain antibody that detects PILR-α/β protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-PILR-α/β antibody (H-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PILR-α/β protein plays a crucial role in immune regulation, particularly through interaction with specific ligands that modulate immune cell responses. PILR-α/β protein is primarily located on the surface of immune cells, where PILR-α/β protein participates in the recognition of ligands that can either activate or inhibit immune signaling pathways. PILR-β, the activating member of the receptor pair, initiates signaling cascades vital for maintaining a balanced immune response, preventing overactivation that could lead to autoimmune disorders. PILR-α and PILR-β genes are situated in a tandem head-to-tail orientation on human chromosome 7, a region rich in genes that contribute to various biological functions, highlighting the importance of this receptor pair in immune system regulation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PILR-α/β Antibody (H-2) References:
- PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta. | Mousseau, DD., et al. 2000. J Biol Chem. 275: 4467-74. PMID: 10660620
- Activation of natural killer cells and dendritic cells upon recognition of a novel CD99-like ligand by paired immunoglobulin-like type 2 receptor. | Shiratori, I., et al. 2004. J Exp Med. 199: 525-33. PMID: 14970179
- Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. | Koga, T., et al. 2004. Nature. 428: 758-63. PMID: 15085135
- The SH3-SAM adaptor HACS1 is up-regulated in B cell activation signaling cascades. | Zhu, YX., et al. 2004. J Exp Med. 200: 737-47. PMID: 15381729
- Comparative analysis of the paired immunoglobulin-like receptor (PILR) locus in six mammalian genomes: duplication, conversion, and the birth of new genes. | Wilson, MD., et al. 2006. Physiol Genomics. 27: 201-18. PMID: 16926269
- Expression, crystallization and preliminary X-ray diffraction analysis of human paired Ig-like type 2 receptor alpha (PILRalpha). | Tabata, S., et al. 2008. Acta Crystallogr Sect F Struct Biol Cryst Commun. 64: 44-6. PMID: 18097101
- PILRalpha is a herpes simplex virus-1 entry coreceptor that associates with glycoprotein B. | Satoh, T., et al. 2008. Cell. 132: 935-44. PMID: 18358807
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PILR-α/β Antibody (H-2) | sc-390847 | 200 µg/ml | $322.00 | |||
PILR-α/β Antibody (H-2): m-IgG Fc BP-HRP Bundle | sc-530283 | 200 µg Ab; 10 µg BP | $361.00 | |||
PILR-α/β Antibody (H-2): m-IgGκ BP-HRP Bundle | sc-523705 | 200 µg Ab, 40 µg BP | $361.00 | |||
PILR-α/β Antibody (H-2): m-IgG2a BP-HRP Bundle | sc-547472 | 200 µg Ab; 10 µg BP | $361.00 | |||
PILR-α/β Antibody (H-2) AC | sc-390847 AC | 500 µg/ml, 25% agarose | $424.00 | |||
PILR-α/β Antibody (H-2) HRP | sc-390847 HRP | 200 µg/ml | $322.00 | |||
PILR-α/β Antibody (H-2) FITC | sc-390847 FITC | 200 µg/ml | $336.00 | |||
PILR-α/β Antibody (H-2) PE | sc-390847 PE | 200 µg/ml | $349.00 | |||
PILR-α/β Antibody (H-2) Alexa Fluor® 488 | sc-390847 AF488 | 200 µg/ml | $364.00 | |||
PILR-α/β Antibody (H-2) Alexa Fluor® 546 | sc-390847 AF546 | 200 µg/ml | $364.00 | |||
PILR-α/β Antibody (H-2) Alexa Fluor® 594 | sc-390847 AF594 | 200 µg/ml | $364.00 | |||
PILR-α/β Antibody (H-2) Alexa Fluor® 647 | sc-390847 AF647 | 200 µg/ml | $364.00 | |||
PILR-α/β Antibody (H-2) Alexa Fluor® 680 | sc-390847 AF680 | 200 µg/ml | $364.00 | |||
PILR-α/β Antibody (H-2) Alexa Fluor® 790 | sc-390847 AF790 | 200 µg/ml | $364.00 |