PICOT Antibody (JF-6): sc-100601

PICOT Antibody (JF-6) is a mouse monoclonal IgG1 antibody that detects PICOT in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). PICOT, also known as GLRX3, GRX3, GRX4, GLRX4, HUSSY-22, TXNL2, or TXNL3, is a 335 amino acid protein characterized by one thioredoxin domain and two glutaredoxin domains, which are crucial for its role in cellular redox regulation. PICOT is primarily localized in the cytoplasm and cell cortex, where PICOT is believed to play a significant role in modulating the thioredoxin system, thereby influencing various cellular processes. Notably, PICOT is involved in the inhibition of cardiac hypertrophy, a condition marked by the thickening of heart muscle often due to high blood pressure, by negatively regulating the signaling pathway of Nuclear factor of activated T-cells (NFAT). Despite containing a thioredoxin domain, PICOT lacks the two redox-reactive cysteines necessary for catalytic activity, indicating that PICOT does not function as a traditional thioredoxin. PICOT expression is prominent in the testis, heart, and spleen, with lower levels found in the thymus, lung, colon, placenta, and small intestine, highlighting PICOT′s potential importance in various physiological contexts. With unique properties and functional implications, anti-PICOT antibody (JF-6) serves as a valuable tool for researchers investigating the roles of PICOT in human health and disease.

The preferred PICOT antibody is PICOT Antibody (D-10): sc-390068.