pICln Antibody (D-1): sc-271454
- pICln Antibody (D-1) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-237 representing full length PICln of human origin
- recommended for detection of pICln of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for pICln Antibody (D-1) for WB applications. These reagents are now offered in bundles with pICln Antibody (D-1) (see ordering information below).
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SEE ALSO...
pICln Antibody (D-1) is a mouse monoclonal IgG1 antibody that detects pICln in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). pICln, a highly conserved and ubiquitously expressed protein, primarily localizes to the cytoplasm and plays a crucial role in the assembly of the spliceosome by interacting with Sm proteins. This interaction is essential for the proper formation of small nuclear ribonucleoproteins (snRNPs), which are vital for pre-mRNA splicing. Additionally, pICln functions as an inhibitor of SnRNP assembly, preventing specific interactions between Sm proteins that are necessary for the formation of the Sm core. Beyond pICln′s role in the methylosome complex, which modifies Sm proteins through symmetrical dimethylarginines, pICln may also act as a swelling-activated anion channel or a channel regulator, highlighting its multifaceted importance in cellular processes. The gene encoding human pICln is located on chromosome 11q14.1, underscoring its significance in human biology and potential implications in various diseases.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
pICln Antibody (D-1) | sc-271454 | 200 µg/ml | $316.00 | |||
pICln Antibody (D-1): m-IgG Fc BP-HRP Bundle | sc-537638 | 200 µg Ab; 10 µg BP | $354.00 | |||
pICln Antibody (D-1): m-IgGκ BP-HRP Bundle | sc-534968 | 200 µg Ab; 40 µg BP | $354.00 | |||
pICln Antibody (D-1): m-IgG1 BP-HRP Bundle | sc-545274 | 200 µg Ab; 20 µg BP | $354.00 |