PI 3-kinase p110β Antibody (B-5): sc-376412
- PI 3-kinase p110β Antibody (B-5) is a mouse monoclonal IgG2a κ, cited in 6 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2-31 at the N-terminus of PI 3-kinase p110β of human origin
- recommended for detection of PI 3-kinase p110β of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PI 3-kinase p110β Antibody (B-5) for WB applications. These reagents are now offered in bundles with PI 3-kinase p110β Antibody (B-5) (see ordering information below).
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PI 3-kinase p110β Antibody (B-5) is a mouse monoclonal IgG2a antibody that detects phosphatidylinositol 3-kinase p110β in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PI 3-kinase p110β plays a crucial role in cellular signaling pathways, particularly in the regulation of cell growth, proliferation, and survival, making PI 3-kinase p110β an important target for research in cancer and metabolic diseases. PI 3-kinase p110β is primarily located in the cytoplasm and is activated by various growth factors, which is significant because PI 3-kinase p110β activation leads to the production of phosphatidylinositol (3,4,5)-trisphosphate, a lipid second messenger that recruits and activates downstream signaling proteins. PI 3-kinase p110β interaction with p85 subunits is essential for regulatory function, as p85 serves as an adapter that stabilizes PI 3-kinase p110β catalytic subunit and enhances activity. Understanding PI 3-kinase p110β dynamics and interactions can provide insights into the mechanisms of diseases where PI 3-kinase signaling is dysregulated, highlighting PI 3-kinase p110β Antibody (B-5) significance in advancing research in this area.
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PI 3-kinase p110β Antibody (B-5) References:
- The PI 3-kinase isoforms p110(alpha) and p110(beta) have differential roles in PDGF- and insulin-mediated signaling. | Hooshmand-Rad, R., et al. 2000. J Cell Sci. 113 Pt 2: 207-14. PMID: 10633072
- Detection of the p110 beta subunit of phosphatidylinositol 3-kinase complexed with neutral endopeptidase. | Shen, R., et al. 2002. Anticancer Res. 22: 2533-8. PMID: 12529960
- PI 3-kinase p110beta: a new target for antithrombotic therapy. | Jackson, SP., et al. 2005. Nat Med. 11: 507-14. PMID: 15834429
- Critical roles of the p110 beta subtype of phosphoinositide 3-kinase in lipopolysaccharide-induced Akt activation and negative regulation of nitrite production in RAW 264.7 cells. | Tsukamoto, K., et al. 2008. J Immunol. 180: 2054-61. PMID: 18250410
- Phosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces. | Schoenwaelder, SM., et al. 2010. J Biol Chem. 285: 2886-96. PMID: 19940148
- The role of PI 3-kinase p110beta in AKT signally, cell survival, and proliferation in human prostate cancer cells. | Hill, KM., et al. 2010. Prostate. 70: 755-64. PMID: 20058239
- PI 3-Kinase p110β regulation of platelet integrin α(IIb)β3. | Jackson, SP. and Schoenwaelder, SM. 2010. Curr Top Microbiol Immunol. 346: 203-24. PMID: 20517720
- The class IA phosphatidylinositol 3-kinase p110-beta subunit is a positive regulator of autophagy. | Dou, Z., et al. 2010. J Cell Biol. 191: 827-43. PMID: 21059846
- PI-3 kinase p110β: a therapeutic target in advanced prostate cancers. | Li, B., et al. 2014. Am J Clin Exp Urol. 2: 188-98. PMID: 25374921
- Direct association of p110 beta phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 beta. | Hu, P. and Schlessinger, J. 1994. Mol Cell Biol. 14: 2577-83. PMID: 8139559
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PI 3-kinase p110β Antibody (B-5) | sc-376412 | 200 µg/ml | $322.00 | |||
PI 3-kinase p110β Antibody (B-5): m-IgG Fc BP-HRP Bundle | sc-537983 | 200 µg Ab; 10 µg BP | $361.00 | |||
PI 3-kinase p110β Antibody (B-5): m-IgGκ BP-HRP Bundle | sc-535485 | 200 µg Ab; 40 µg BP | $361.00 | |||
PI 3-kinase p110β Antibody (B-5): m-IgG2a BP-HRP Bundle | sc-548171 | 200 µg Ab; 10 µg BP | $361.00 | |||
PI 3-kinase p110β (B-5) Neutralizing Peptide | sc-376412 P | 100 µg/0.5 ml | $69.00 |