PI 3-kinase p110β Antibody (B-5): sc-376412

PI 3-kinase p110β Antibody (B-5) is a mouse monoclonal IgG2a antibody that detects phosphatidylinositol 3-kinase p110β in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PI 3-kinase p110β plays a crucial role in cellular signaling pathways, particularly in the regulation of cell growth, proliferation, and survival, making PI 3-kinase p110β an important target for research in cancer and metabolic diseases. PI 3-kinase p110β is primarily located in the cytoplasm and is activated by various growth factors, which is significant because PI 3-kinase p110β activation leads to the production of phosphatidylinositol (3,4,5)-trisphosphate, a lipid second messenger that recruits and activates downstream signaling proteins. PI 3-kinase p110β interaction with p85 subunits is essential for regulatory function, as p85 serves as an adapter that stabilizes PI 3-kinase p110β catalytic subunit and enhances activity. Understanding PI 3-kinase p110β dynamics and interactions can provide insights into the mechanisms of diseases where PI 3-kinase signaling is dysregulated, highlighting PI 3-kinase p110β Antibody (B-5) significance in advancing research in this area.

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PI 3-kinase p110β Antibody (B-5) References:

1. The PI 3-kinase isoforms p110(alpha) and p110(beta) have differential roles in PDGF- and insulin-mediated signaling.  |  Hooshmand-Rad, R., et al. 2000. J Cell Sci. 113 Pt 2: 207-14. PMID: 10633072
2. Detection of the p110 beta subunit of phosphatidylinositol 3-kinase complexed with neutral endopeptidase.  |  Shen, R., et al. 2002. Anticancer Res. 22: 2533-8. PMID: 12529960
3. PI 3-kinase p110beta: a new target for antithrombotic therapy.  |  Jackson, SP., et al. 2005. Nat Med. 11: 507-14. PMID: 15834429
4. Critical roles of the p110 beta subtype of phosphoinositide 3-kinase in lipopolysaccharide-induced Akt activation and negative regulation of nitrite production in RAW 264.7 cells.  |  Tsukamoto, K., et al. 2008. J Immunol. 180: 2054-61. PMID: 18250410
5. Phosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces.  |  Schoenwaelder, SM., et al. 2010. J Biol Chem. 285: 2886-96. PMID: 19940148
6. The role of PI 3-kinase p110beta in AKT signally, cell survival, and proliferation in human prostate cancer cells.  |  Hill, KM., et al. 2010. Prostate. 70: 755-64. PMID: 20058239
7. PI 3-Kinase p110β regulation of platelet integrin α(IIb)β3.  |  Jackson, SP. and Schoenwaelder, SM. 2010. Curr Top Microbiol Immunol. 346: 203-24. PMID: 20517720
8. The class IA phosphatidylinositol 3-kinase p110-beta subunit is a positive regulator of autophagy.  |  Dou, Z., et al. 2010. J Cell Biol. 191: 827-43. PMID: 21059846
9. PI-3 kinase p110β: a therapeutic target in advanced prostate cancers.  |  Li, B., et al. 2014. Am J Clin Exp Urol. 2: 188-98. PMID: 25374921
10. Direct association of p110 beta phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 beta.  |  Hu, P. and Schlessinger, J. 1994. Mol Cell Biol. 14: 2577-83. PMID: 8139559

The preferred PI 3-kinase p110β antibody is PI 3-kinase p110β Antibody (C-8): sc-376641.