PI 3-kinase p110α Antibody (E-7): sc-518070
- PI 3-kinase p110α Antibody (E-7) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 1002-1029 at the C-terminus of PI 3-kinase p110α of human origin
- PI 3-kinase p110 alpha Antibody (E-7) is recommended for detection of PI 3-kinase p110α of human origin by WB, IP, IF and ELISA
- Anti-PI 3-kinase p110 alpha Antibody (E-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP is the preferred secondary detection reagent for PI 3-kinase p110α Antibody (E-7) for WB applications. This reagent is now offered in a bundle with PI 3-kinase p110α Antibody (E-7) (see ordering information below).
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PI 3-kinase p110α Antibody (E-7) is a mouse monoclonal IgG2b kappa light chain antibody that detects PI 3-kinase p110α of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PI 3-kinase p110α (E-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The phosphatidylinositol 3-kinase (PI 3-kinase) pathway plays a crucial role in cellular functions such as growth, proliferation, and survival, making the study of PI 3-kinase components vital for understanding various diseases, including cancer. PI 3-kinase p110α is particularly important as PI 3-kinase p110α is frequently mutated in several types of cancer, leading to aberrant signaling and uncontrolled cell growth. Understanding PI 3-kinase p110α interactions with PI 3-kinase regulatory subunit p85 is essential, as p85 serves as an adapter that links PI 3-kinase p110α to activated protein tyrosine kinases, thereby facilitating the activation of downstream signaling pathways. PI 3-kinase p110α ability to interact with both p85α and p85β highlights PI 3-kinase p110α versatility and importance in the PI 3-kinase signaling cascade, which is critical for maintaining cellular homeostasis and responding to extracellular signals.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PI 3-kinase p110α Antibody (E-7) References:
- Mutation of the PIK3CA oncogene in human cancers. | Karakas, B., et al. 2006. Br J Cancer. 94: 455-9. PMID: 16449998
- Non-invasive imaging of phosphoinositide-3-kinase-catalytic-subunit-alpha (PIK3CA) promoter modulation in small animal models. | Gaikwad, SM., et al. 2013. PLoS One. 8: e55971. PMID: 23393606
- Oncogenic PIK3CA promotes cellular stemness in an allele dose-dependent manner. | Madsen, RR., et al. 2019. Proc Natl Acad Sci U S A. 116: 8380-8389. PMID: 30948643
- PIK3CA and PTEN Genes Expressions in Breast Cancer. | Alowiri, NH., et al. 2019. Asian Pac J Cancer Prev. 20: 2841-2846. PMID: 31554385
- PIK3CA gene aberrancy and role in targeted therapy of solid malignancies. | Willis, O., et al. 2020. Cancer Gene Ther. 27: 634-644. PMID: 31988478
- Use of Liquid Biopsy to Detect PIK3CA Mutation in Metastatic Breast Cancer. | Nakai, M., et al. 2022. J Nippon Med Sch. 89: 66-71. PMID: 33692304
- Double PIK3CA Alterations and Parallel Evolution in Colorectal Cancers. | Lin, MT., et al. 2022. Am J Clin Pathol. 157: 244-251. PMID: 34519764
- Treatment of two infants with PIK3CA-related overgrowth spectrum by alpelisib. | Morin, G., et al. 2022. J Exp Med. 219: PMID: 35080595
- PIK3CA mutations-mediated downregulation of circLHFPL2 inhibits colorectal cancer progression via upregulating PTEN. | Chong, X., et al. 2022. Mol Cancer. 21: 118. PMID: 35619132
- PIK3CA Mutational Analysis in Patients With Macrodactyly. | Becker, J., et al. 2022. Pediatr Dev Pathol. 25: 624-634. PMID: 36314082
- Tipifarnib Potentiates the Antitumor Effects of PI3Kα Inhibition in PIK3CA- and HRAS-Dysregulated HNSCC via Convergent Inhibition of mTOR Activity. | Smith, AE., et al. 2023. Cancer Res. 83: 3252-3263. PMID: 37339176
- Molecular cloning, cDNA sequence, and chromosomal localization of the human phosphatidylinositol 3-kinase p110 alpha (PIK3CA) gene. | Volinia, S., et al. 1994. Genomics. 24: 472-7. PMID: 7713498
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PI 3-kinase p110α Antibody (E-7) | sc-518070 | 200 µg/ml | $316.00 | |||
PI 3-kinase p110α Antibody (E-7): m-IgG2b BP-HRP Bundle | sc-548824 | 200 µg Ab; 10 µg BP | $354.00 | |||
PI 3-kinase p110α Antibody (E-7) AC | sc-518070 AC | 500 µg/ml, 25% agarose | $416.00 | |||
PI 3-kinase p110α Antibody (E-7) HRP | sc-518070 HRP | 200 µg/ml | $316.00 | |||
PI 3-kinase p110α Antibody (E-7) FITC | sc-518070 FITC | 200 µg/ml | $330.00 | |||
PI 3-kinase p110α Antibody (E-7) PE | sc-518070 PE | 200 µg/ml | $343.00 | |||
PI 3-kinase p110α Antibody (E-7) Alexa Fluor® 488 | sc-518070 AF488 | 200 µg/ml | $357.00 | |||
PI 3-kinase p110α Antibody (E-7) Alexa Fluor® 546 | sc-518070 AF546 | 200 µg/ml | $357.00 | |||
PI 3-kinase p110α Antibody (E-7) Alexa Fluor® 594 | sc-518070 AF594 | 200 µg/ml | $357.00 | |||
PI 3-kinase p110α Antibody (E-7) Alexa Fluor® 647 | sc-518070 AF647 | 200 µg/ml | $357.00 | |||
PI 3-kinase p110α Antibody (E-7) Alexa Fluor® 680 | sc-518070 AF680 | 200 µg/ml | $357.00 | |||
PI 3-kinase p110α Antibody (E-7) Alexa Fluor® 790 | sc-518070 AF790 | 200 µg/ml | $357.00 |