PHF6 Antibody (G-9): sc-271767

PHF6 Antibody (G-9) is a mouse monoclonal IgG1 antibody that detects PHF6 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PHF6, also known as PHD finger protein 6 or BORJ, is a 365 amino acid protein that plays a crucial role in transcriptional regulation and is predominantly localized in the nucleus. The presence of two PHD-type zinc fingers in its structure allows PHF6 to interact with specific DNA sequences, thereby influencing gene expression and cellular responses to various stimuli. This function is particularly important as PHF6 helps maintain cellular homeostasis and responds to DNA damage, where PHF6 undergoes phosphorylation, likely mediated by ATM or ATR kinases. Notably, mutations in the gene encoding PHF6 are linked to Boerjeson-Forssman-Lehmann syndrome (BFLS), an X-linked recessive disorder characterized by a range of symptoms including mental retardation, epilepsy, and obesity, underscoring PHF6′s significance in normal development and function. Anti-PHF6 antibody (G-9) is an essential tool for researchers studying the molecular mechanisms underlying these conditions and the broader implications of transcriptional regulation in health and disease.

The preferred PHF6 antibody is PHF6 Antibody (H-4): sc-365237.