PHF6 Antibody (B-9): sc-365013

PHF6 Antibody (B-9) is a mouse monoclonal IgG2b antibody that detects PHF6 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PHF6, also known as PHD finger protein 6 or BORJ, is a 365 amino acid protein that plays a crucial role in transcriptional regulation and is predominantly localized in the nucleus. The presence of two PHD-type zinc fingers in PHF6′s structure allows binding to specific DNA sequences, thereby influencing gene expression and cellular responses to various stimuli. This function maintains cellular homeostasis and responds to DNA damage, which is essential for preventing genomic instability. Notably, upon DNA damage, PHF6 undergoes phosphorylation, likely mediated by ATM or ATR kinases, which can modulate activity and interactions. Mutations in the gene encoding PHF6 are linked to Boerjeson-Forssman-Lehmann syndrome (BFLS), an X-linked recessive disorder characterized by a range of symptoms including mental retardation, epilepsy, and obesity, highlighting PHF6′s significance in normal development and cellular function. Anti-PHF6 antibody (B-9) is an invaluable tool for researchers studying the molecular mechanisms underlying transcriptional regulation and the pathophysiology of related disorders.

The preferred PHF6 antibody is PHF6 Antibody (H-4): sc-365237.