PGRMC2 Antibody (F-3): sc-374624
- PGRMC2 Antibody (F-3) is a mouse monoclonal IgG2b κ PGRMC2 antibody, cited in 7 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 1-5 near the N-terminus of PGRMC2 of human origin
- PGRMC2 Antibody (F-3) is recommended for detection of PGRMC2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-PGRMC2 Antibody (F-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PGRMC2 Antibody (F-3) for WB and IHC(P) applications. These reagents are now offered in bundles with PGRMC2 Antibody (F-3) (see ordering information below).
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PGRMC2 Antibody (F-3) is a mouse monoclonal IgG2b kappa light chain antibody that detects PGRMC2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-PGRMC2 antibody (F-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PGRMC2, also known as progesterone receptor membrane component 2, DG6, or progesterone membrane-binding protein, is a single-pass membrane protein that belongs to the cytochrome b5 family, specifically the membrane-associated progesterone receptor subfamily. PGRMC2 plays a crucial role in the reproductive system, particularly in sperm function, as PGRMC2 is expressed in sperm and acts as a steroid receptor, facilitating the progesterone-dependent acrosome reaction, which is essential for fertilization. PGRMC2 shares approximately 50% sequence identity with PGRMC1. Loss of the gene encoding PGRMC2 has been linked to increased metastasis in uterine endocervical adenocarcinomas, suggesting PGRMC2 may have a protective role against the spread of cancer in this context.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PGRMC2 Antibody (F-3) References:
- Putative gene loci associated with carcinogenesis and metastasis of endocervical adenocarcinomas of uterus determined by conventional and array-based CGH. | Hirai, Y., et al. 2004. Am J Obstet Gynecol. 191: 1173-82. PMID: 15507938
- Classic and non-classic progesterone receptors are both expressed in human spermatozoa. | Lösel, R., et al. 2005. Horm Metab Res. 37: 10-4. PMID: 15702432
- Interactions between progesterone and tumor necrosis factor-alpha in the regulation of primordial follicle assembly. | Nilsson, EE., et al. 2006. Reproduction. 132: 877-86. PMID: 17127748
- Progesterone receptor membrane component 1: an integrative review. | Cahill, MA. 2007. J Steroid Biochem Mol Biol. 105: 16-36. PMID: 17583495
- Cloning and tissue expression of two putative steroid membrane receptors. | Gerdes, D., et al. 1998. Biol Chem. 379: 907-11. PMID: 9705155
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PGRMC2 Antibody (F-3) | sc-374624 | 200 µg/ml | $316.00 | |||
PGRMC2 Antibody (F-3): m-IgG Fc BP-HRP Bundle | sc-529783 | 200 µg Ab; 10 µg BP | $354.00 | |||
PGRMC2 Antibody (F-3): m-IgGκ BP-HRP Bundle | sc-522793 | 200 µg Ab, 40 µg BP | $354.00 | |||
PGRMC2 Antibody (F-3) AC | sc-374624 AC | 500 µg/ml, 25% agarose | $416.00 | |||
PGRMC2 Antibody (F-3) HRP | sc-374624 HRP | 200 µg/ml | $316.00 | |||
PGRMC2 Antibody (F-3) FITC | sc-374624 FITC | 200 µg/ml | $330.00 | |||
PGRMC2 Antibody (F-3) PE | sc-374624 PE | 200 µg/ml | $343.00 | |||
PGRMC2 Antibody (F-3) Alexa Fluor® 488 | sc-374624 AF488 | 200 µg/ml | $357.00 | |||
PGRMC2 Antibody (F-3) Alexa Fluor® 546 | sc-374624 AF546 | 200 µg/ml | $357.00 | |||
PGRMC2 Antibody (F-3) Alexa Fluor® 594 | sc-374624 AF594 | 200 µg/ml | $357.00 | |||
PGRMC2 Antibody (F-3) Alexa Fluor® 647 | sc-374624 AF647 | 200 µg/ml | $357.00 | |||
PGRMC2 Antibody (F-3) Alexa Fluor® 680 | sc-374624 AF680 | 200 µg/ml | $357.00 | |||
PGRMC2 Antibody (F-3) Alexa Fluor® 790 | sc-374624 AF790 | 200 µg/ml | $357.00 | |||
PGRMC2 (F-3) Neutralizing Peptide | sc-374624 P | 100 µg/0.5 ml | $68.00 |