PGM 1 Antibody (D-8): sc-373796

PGM 1 Antibody (D-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects PGM 1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PGM 1 (D-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PGM 1, a member of the phosphohexose mutase family, plays a crucial role in carbohydrate metabolism, specifically in glycogen catabolism and synthesis. PGM 1 catalyzes the interconversion of glucose-1-phosphate and glucose-6-phosphate, which is vital for energy production and regulation of glucose levels in the body. PGM 1′s activity is essential for maintaining metabolic homeostasis, particularly during periods of fasting or intense physical activity. PGM 1 is located in the cytoplasm, where PGM 1 can efficiently participate in metabolic pathways, ensuring that glucose is readily available for energy production when needed. PGM 1 exhibits significant polymorphism, with multiple variants arising from genetic mutations and recombination events, which can influence enzymatic activity and regulation. Understanding PGM 1′s functional dynamics is important for elucidating its role in metabolic disorders and potential therapeutic targets.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

PGM 1 Antibody (D-8) References:

1. Mapping recombination hotspots in human phosphoglucomutase (PGM1).  |  Yip, SP., et al. 1999. Hum Mol Genet. 8: 1699-706. PMID: 10441333
2. Cloning and characterization of the phosphoglucomutase of Trypanosoma cruzi and functional complementation of a Saccharomyces cerevisiae PGM null mutant.  |  Penha, LL., et al. 2005. Glycobiology. 15: 1359-67. PMID: 16037487
3. Streptococcus iniae phosphoglucomutase is a virulence factor and a target for vaccine development.  |  Buchanan, JT., et al. 2005. Infect Immun. 73: 6935-44. PMID: 16177373
4. Overexpression of Mycobacterium tuberculosis manB, a phosphomannomutase that increases phosphatidylinositol mannoside biosynthesis in Mycobacterium smegmatis and mycobacterial association with human macrophages.  |  McCarthy, TR., et al. 2005. Mol Microbiol. 58: 774-90. PMID: 16238626
5. Lithium induces phosphoglucomutase activity in various tissues of rats and in bipolar patients.  |  Csutora, P., et al. 2006. Int J Neuropsychopharmacol. 9: 613-9. PMID: 16259646
6. Improvement of galactose uptake in Saccharomyces cerevisiae through overexpression of phosphoglucomutase: example of transcript analysis as a tool in inverse metabolic engineering.  |  Bro, C., et al. 2005. Appl Environ Microbiol. 71: 6465-72. PMID: 16269670
7. Increased phosphoglucomutase activity suppresses the galactose growth defect associated with elevated levels of Ras signaling in S. cerevisiae.  |  Howard, SC., et al. 2006. Curr Genet. 49: 1-6. PMID: 16292676
8. A phylogeny for the principal alleles of the human phosphoglucomutase-1 locus.  |  Takahashi, N., et al. 1982. Proc Natl Acad Sci U S A. 79: 6636-40. PMID: 6216484
9. Intragenic recombination at the human phosphoglucomutase 1 locus: predictions fulfilled.  |  Takahashi, N. and Neel, JV. 1993. Proc Natl Acad Sci U S A. 90: 10725-9. PMID: 7902567

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PGM 1 Antibody (D-8) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-PGM 1 Antibody (D-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PGM 1 Antibody (D-8) Specifications

Alternate Product Name: PGM 1

Product Clone Name: D-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 407-514

Epitope Target: PGM 1

Epitope Species: human

Product Reactivity/Detection: PGM 1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for PGM 1 Antibody (D-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin