PGM 1 Activators

The class of PGM1 Modulators consists of compounds that can influence the pathways, substrates, and products involved with PGM1. Glucose-1-phosphate and glucose-6-phosphate are direct substrates and products of PGM1, and their availability directly influences the activity of the enzyme. An increase in the concentration of these substrates can lead to increased conversion and therefore, increased activity of PGM1. Fructose-6-phosphate, Fructose-1,6-bisphosphate, Phosphoenolpyruvate, 3-Phosphoglycerate, and 2-Phosphoglycerate are all involved in the glycolytic pathway, of which PGM1 is also a part. Their levels can impact the flux through this pathway, and, in turn, can affect the activity of PGM1 indirectly.

Adenosine diphosphate (ADP), Adenosine triphosphate (ATP), and Uridine diphosphate glucose (UDPG) are involved in the regulation of the glycolytic and glycogen synthesis pathways, which can indirectly affect the activity of PGM1. Their concentrations can influence the rate of these metabolic pathways and indirectly influence the activity of PGM1. Inosine diphosphate (IDP) can bind to PGM1 and affect its activity. IDP is structurally similar to the substrates of PGM1 and its binding can alter the activity of the enzyme. Lastly, Pyruvate, the end product of the glycolytic pathway, can indirectly influence the activity of PGM1 by affecting the overall flux of the pathway.