PGLS Antibody (B-10): sc-514629

PGLS Antibody (B-10) is a mouse monoclonal IgG1 antibody that detects PGLS (6-phosphogluconolactonase) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PGLS is a crucial enzyme in the pentose phosphate pathway, catalyzing the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate, which is essential for cellular metabolism and the generation of NADPH and ribose-5-phosphate. These products are vital for anabolic reactions and nucleotide synthesis, respectively, highlighting PGLS′s importance in maintaining cellular function and redox balance. PGLS consists of 258 amino acids and is highly conserved across species, sharing significant sequence similarity with various homologs, including yeast and bacterial proteins. Notably, mutations or deficiencies in PGLS can lead to metabolic disorders, such as hemolytic anemia when combined with G6PD deficiency, underscoring PGLS′s clinical relevance. The gene encoding PGLS is located on human chromosome 19p13.11, further emphasizing PGLS′s significance in human health and disease. Anti-PGLS antibody (B-10) is an invaluable tool for researchers studying this enzyme′s role in various biological processes and disease states.

The preferred PGLS antibody is PGLS Antibody (G-7): sc-398833.