PGLS Activators

6-Phosphogluconolactonase (PGLS), encoded by the PGLS gene in humans, is an enzyme involved in the pentose phosphate pathway (PPP), an essential metabolic pathway that generates NADPH and pentoses (5-carbon sugars).Specifically, PGLS catalyzes the second step of the PPP, the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. This step is essential for the continuation of the pathway, which plays a critical role in cellular processes.The PPP has two primary functions: NADPH generation and the production of ribose-5-phosphate. NADPH is a key molecule for various cellular processes, including detoxification reactions, biosynthesis processes, and the maintenance of redox balance. Ribose-5-phosphate, on the other hand, is a precursor for the synthesis of nucleotides and nucleic acids, essential for DNA and RNA production.

Given its role in the PPP, PGLS is indirectly involved in these processes. Thus, it contributes to maintaining cellular health by supporting antioxidative defense, biosynthesis pathways, and nucleotide production.Alterations in the PPP and its enzymes, including PGLS, can lead to imbalances in cellular redox state and nucleotide synthesis, potentially contributing to various diseases, including cancer and neurodegenerative disorders.In summary, 6-phosphogluconolactonase is a crucial enzyme in the pentose phosphate pathway, contributing to antioxidant defense, biosynthesis processes, and nucleotide production.