PGE synthase Antibody (H-3): sc-365844

PGE synthase Antibody (H-3) is a mouse monoclonal IgG2b kappa light chain antibody that detects PGE synthase in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-PGE synthase antibody (H-3) is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Prostaglandin E Synthase (PGE synthase), also known as PIG12 and MGST1-L1, functions as a key enzyme within the MAPEG protein superfamily, which includes membrane-associated proteins involved in eicosanoid and glutathione metabolism. PGE synthase (H-3) monoclonal antibody recognizes PGE synthase in seminal vesicles, deferent ducts, kidney, heart, and spleen, highlighting significant roles in various physiological processes, particularly inflammation and immune response. Proinflammatory cytokines such as interleukin-1 beta can upregulate PGE synthase expression, suggesting involvement in inflammatory diseases. Research has linked PGE synthase to Alzheimer′s disease progression, making this protein a potential therapeutic target. Located on chromosome 9q34, the human PGE synthase gene provides valuable insights for biological research.

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PGE synthase Antibody (H-3) References:

1. Common structural features of MAPEG -- a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism.  |  Jakobsson, PJ., et al. 1999. Protein Sci. 8: 689-92. PMID: 10091672
2. Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target.  |  Jakobsson, PJ., et al. 1999. Proc Natl Acad Sci U S A. 96: 7220-5. PMID: 10377395
3. Expression of prostaglandin E synthase mRNA is induced in beta-amyloid treated rat astrocytes.  |  Satoh, K., et al. 2000. Neurosci Lett. 283: 221-3. PMID: 10754227
4. Human glutathione dependent prostaglandin E synthase: gene structure and regulation.  |  Forsberg, L., et al. 2000. FEBS Lett. 471: 78-82. PMID: 10760517
5. Prostaglandin E synthase in the pathophysiology of arthritis.  |  Kojima, F., et al. 2005. Fundam Clin Pharmacol. 19: 255-61. PMID: 15910650
6. Prostaglandin E synthase: a novel drug target for inflammation and cancer.  |  Murakami, M. and Kudo, I. 2006. Curr Pharm Des. 12: 943-54. PMID: 16533161
7. Prostaglandin E synthase is upregulated by Gas6 during cancer-induced venous thrombosis.  |  Aghourian, MN., et al. 2016. Blood. 127: 769-77. PMID: 26585956
8. Linking microsomal prostaglandin E Synthase-1/PGE-2 pathway with miR-15a and -186 expression: Novel mechanism of VEGF modulation in prostate cancer.  |  Terzuoli, E., et al. 2016. Oncotarget. 7: 44350-44364. PMID: 27322147
9. Cytosolic Prostaglandin E Synthase Is Involved in c-Fos Expression in Rat Fibroblastic 3Y1 Cells.  |  Nakatani, Y., et al. 2017. Biol Pharm Bull. 40: 1963-1967. PMID: 29093345
10. Immunochemical and kinetic evidence for two different prostaglandin H-prostaglandin E isomerases in sheep vesicular gland microsomes.  |  Tanaka, Y., et al. 1987. J Biol Chem. 262: 1374-81. PMID: 3100531
11. Prostaglandin endoperoxide E isomerase from bovine vesicular gland microsomes, a glutathione-requiring enzyme.  |  Ogino, N., et al. 1977. J Biol Chem. 252: 890-5. PMID: 838703
12. Two types of microsomal prostaglandin E synthase: glutathione-dependent and -independent prostaglandin E synthases.  |  Watanabe, K., et al. 1997. Biochem Biophys Res Commun. 235: 148-52. PMID: 9196052

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PGE synthase Antibody (H-3) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-PGE synthase Antibody (H-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PGE synthase Antibody (H-3) Specifications

Alternate Product Name: PGE synthase

Product Clone Name: H-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 51-82

Epitope Target: PGE synthase

Epitope Species: human

Product Reactivity/Detection: PGE synthase

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for PGE synthase Antibody (H-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin