PGE synthase Antibody (B-6): sc-166309

PGE synthase Antibody (B-6) is a mouse monoclonal IgG1 antibody that detects PGE synthase in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). PGE synthase, also known as PIG12 and MGST1-L1, is a crucial enzyme within the MAPEG superfamily, which comprises membrane-associated proteins that play significant roles in eicosanoid and glutathione metabolism. Anti-PGE synthase antibody (B-6) recognizes protein predominantly expressed in seminal vesicles, deferent ducts, kidney, heart, and spleen, and expression can be induced by the proinflammatory cytokine IL-1β, highlighting involvement in inflammatory responses. Notably, PGE synthase is glutathione-dependent in enzymatic activity across various organs, which is essential for the synthesis of prostaglandins that mediate numerous physiological processes, including inflammation and pain. Furthermore, localization of human PGE synthase to chromosome 9q34 suggests potential implications in genetic studies related to diseases such as Alzheimer′s, where activity may influence disease progression. PGE synthase (B-6) antibody is an invaluable tool for researchers investigating the role of PGE synthase in health and disease.

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PGE synthase Antibody (B-6) References:

1. Prostaglandin E synthase, a terminal enzyme for prostaglandin E2 biosynthesis.  |  Kudo, I. and Murakami, M. 2005. J Biochem Mol Biol. 38: 633-8. PMID: 16336776
2. Microsomal prostaglandin E synthase-1 and 5-lipoxygenase: potential drug targets in cancer.  |  Rådmark, O. and Samuelsson, B. 2010. J Intern Med. 268: 5-14. PMID: 20497297
3. Microsomal prostaglandin E synthase-1 protects against Fas-induced liver injury.  |  Yao, L., et al. 2016. Am J Physiol Gastrointest Liver Physiol. 310: G1071-80. PMID: 27102561
4. An Update of Microsomal Prostaglandin E Synthase-1 and PGE2 Receptors in Cardiovascular Health and Diseases.  |  Yang, G. and Chen, L. 2016. Oxid Med Cell Longev. 2016: 5249086. PMID: 27594972
5. Inhibition of microsomal prostaglandin E synthase-1 facilitates liver repair after hepatic injury in mice.  |  Nishizawa, N., et al. 2018. J Hepatol. 69: 110-120. PMID: 29458169
6. Inhibition of Microsomal Prostaglandin E Synthase-1 in Cancer-Associated Fibroblasts Suppresses Neuroblastoma Tumor Growth.  |  Kock, A., et al. 2018. EBioMedicine. 32: 84-92. PMID: 29804818
7. mPGES-1 (Microsomal Prostaglandin E Synthase-1) Mediates Vascular Dysfunction in Hypertension Through Oxidative Stress.  |  Avendaño, MS., et al. 2018. Hypertension. 72: 492-502. PMID: 29891646
8. Gene Deletion of Microsomal Prostaglandin E Synthase-1 Suppresses Chemically Induced Skin Carcinogenesis.  |  Sasaki, Y., et al. 2021. Anticancer Res. 41: 1307-1314. PMID: 33788722
9. Upregulation of prostaglandin E2 by inducible microsomal prostaglandin E synthase-1 in colon cancer.  |  Kim, YH. and Kim, KJ. 2022. Ann Coloproctol. 38: 153-159. PMID: 34465013
10. Microsomal prostaglandin E synthase-1 is involved in the metabolic and cardiovascular alterations associated with obesity.  |  Ballesteros-Martínez, C., et al. 2022. Br J Pharmacol. 179: 2733-2753. PMID: 34877656

The preferred PGE synthase antibody is PGE synthase Antibody (H-3): sc-365844.