PGE synthase Antibody (A-3): sc-166308
- PGE synthase Antibody (A-3) is a mouse monoclonal IgG1 κ PGE synthase antibody, cited in 7 publications, provided at 200 µg/ml
- raised against amino acids 1-152 representing full length PGE synthase of human origin
- PGE synthase Antibody (A-3) is recommended for detection of PGE synthase of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-PGE synthase Antibody (A-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PGE synthase Antibody (A-3) for WB and IHC(P) applications. These reagents are now offered in bundles with PGE synthase Antibody (A-3) (see ordering information below).
QUICK LINKS
PGE synthase Antibody (A-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects PGE synthase of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-PGE synthase antibody (A-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Prostaglandin E Synthase (PGE synthase), also known as PIG12 and MGST1-L1, is a crucial enzyme within the MAPEG protein superfamily, which comprises membrane-associated proteins that play significant roles in eicosanoid and glutathione metabolism. PGE synthase localizes predominantly in membranes of seminal vesicles, deferent ducts, kidney, heart, and spleen, where PGE synthase facilitates the conversion of prostaglandin H2 to prostaglandin E2, a key mediator in inflammatory responses. Proinflammatory cytokines such as IL-1β can induce PGE synthase expression, highlighting PGE synthase′s role in inflammatory processes and potential implications in diseases like Alzheimer′s. Human PGE synthase is located on chromosome 9q34, and PGE synthase′s glutathione-dependent enzymatic activity underscores its importance in maintaining cellular homeostasis and responding to oxidative stress.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PGE synthase Antibody (A-3) References:
- Characterization of microsomal prostaglandin E synthase 1 inhibitors. | Korotkova, M. and Jakobsson, PJ. 2014. Basic Clin Pharmacol Toxicol. 114: 64-9. PMID: 24138533
- Inhibition of microsomal prostaglandin E synthase-1 as targeted therapy in cancer treatment. | Larsson, K. and Jakobsson, PJ. 2015. Prostaglandins Other Lipid Mediat. 120: 161-5. PMID: 26100239
- Role of microsomal prostaglandin E synthase-1 (mPGES-1)-derived prostaglandin E2 in colon carcinogenesis. | Sasaki, Y., et al. 2015. Prostaglandins Other Lipid Mediat. 121: 42-5. PMID: 26150361
- Microsomal prostaglandin E synthase-1 is a critical factor in dopaminergic neurodegeneration in Parkinson's disease. | Ikeda-Matsuo, Y., et al. 2019. Neurobiol Dis. 124: 81-92. PMID: 30423474
- Targeting microsomal prostaglandin E synthase 1 to develop drugs treating the inflammatory diseases. | Wang, Q., et al. 2021. Am J Transl Res. 13: 391-419. PMID: 33527033
- Inducible Prostaglandin E Synthase as a Pharmacological Target for Ischemic Stroke. | Li, L., et al. 2022. Neurotherapeutics. 19: 366-385. PMID: 35099767
- Transient inhibition of microsomal prostaglandin E synthase-1 after status epilepticus blunts brain inflammation and is neuroprotective. | Yasmen, N., et al. 2023. Mol Brain. 16: 14. PMID: 36694204
- Microsomal Prostaglandin E Synthase-1 and -2: Emerging Targets in Non-Alcoholic Fatty Liver Disease. | Kotsos, D. and Tziomalos, K. 2023. Int J Mol Sci. 24: PMID: 36769370
- Microsomal prostaglandin E synthase-1 inhibition prevents adverse cardiac remodelling after myocardial infarction in mice. | Zhang, Y., et al. 2023. Br J Pharmacol. 180: 1981-1998. PMID: 36788645
- The inducible prostaglandin E synthase (mPGES-1) in neuroinflammatory disorders. | Sluter, MN., et al. 2023. Exp Biol Med (Maywood). 248: 811-819. PMID: 37515545
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PGE synthase Antibody (A-3) | sc-166308 | 200 µg/ml | $316.00 | |||
PGE synthase Antibody (A-3): m-IgG Fc BP-HRP Bundle | sc-528941 | 200 µg Ab; 10 µg BP | $354.00 | |||
PGE synthase Antibody (A-3): m-IgGκ BP-HRP Bundle | sc-521563 | 200 µg Ab, 40 µg BP | $354.00 | |||
PGE synthase Antibody (A-3): m-IgG1 BP-HRP Bundle | sc-543226 | 200 µg Ab; 20 µg BP | $354.00 | |||
PGE synthase Antibody (A-3) AC | sc-166308 AC | 500 µg/ml, 25% agarose | $416.00 | |||
PGE synthase Antibody (A-3) HRP | sc-166308 HRP | 200 µg/ml | $316.00 | |||
PGE synthase Antibody (A-3) FITC | sc-166308 FITC | 200 µg/ml | $330.00 | |||
PGE synthase Antibody (A-3) PE | sc-166308 PE | 200 µg/ml | $343.00 | |||
PGE synthase Antibody (A-3) Alexa Fluor® 488 | sc-166308 AF488 | 200 µg/ml | $357.00 | |||
PGE synthase Antibody (A-3) Alexa Fluor® 546 | sc-166308 AF546 | 200 µg/ml | $357.00 | |||
PGE synthase Antibody (A-3) Alexa Fluor® 594 | sc-166308 AF594 | 200 µg/ml | $357.00 | |||
PGE synthase Antibody (A-3) Alexa Fluor® 647 | sc-166308 AF647 | 200 µg/ml | $357.00 | |||
PGE synthase Antibody (A-3) Alexa Fluor® 680 | sc-166308 AF680 | 200 µg/ml | $357.00 | |||
PGE synthase Antibody (A-3) Alexa Fluor® 790 | sc-166308 AF790 | 200 µg/ml | $357.00 |