PGD2 synthase Antibody (H-10): sc-514880

PGD2 synthase Antibody (H-10) is a mouse monoclonal IgM antibody that detects PGD2 synthase in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PGD2 synthase plays a crucial role in the immune system by catalyzing the conversion of prostaglandin H2 (PGH2) to prostaglandin D2 (PGD2), a lipid mediator involved in various physiological processes, including inflammation and sleep regulation. The importance of PGD2 lies in its ability to modulate immune responses and its involvement in the pathophysiology of several diseases, such as asthma and allergic reactions. PGD2 synthase is primarily located in the cytoplasm of human cells, particularly in megakaryoblastic CMK cells, where expression occurs before differentiation into platelets, which lack PGD2 synthase activity. This localization highlights PGD2 synthase′s role in platelet formation and function, as well as potential impact on vascular biology. The human PGD2 synthase gene is mapped to chromosome 9q34.3 and exhibits species-specific expression patterns, with the human variant being widely distributed compared to its mouse counterpart, which is limited to oviduct and skin. PGD2 synthase is distinct from other members of the PGD synthase family, such as PGD synthase, which is dependent on glutathione for activity, underscoring unique biochemical pathways that PGD2 synthase participates in.

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PGD2 synthase Antibody (H-10) References:

1. Mammalian lipocalin-type prostaglandin D2 synthase in the fluids of the male genital tract: putative biochemical and physiological functions.  |  Fouchécourt, S., et al. 2002. Biol Reprod. 66: 458-67. PMID: 11804963
2. Essential role for hematopoietic prostaglandin D2 synthase in the control of delayed type hypersensitivity.  |  Trivedi, SG., et al. 2006. Proc Natl Acad Sci U S A. 103: 5179-84. PMID: 16547141
3. Loss of prostaglandin D2 synthase: a key molecular event in the transition of a low-grade astrocytoma to an anaplastic astrocytoma.  |  Payne, CA., et al. 2008. Mol Cancer Ther. 7: 3420-8. PMID: 18852145
4. Increased expression of lipocalin-type prostaglandin D2 synthase in osteoarthritic cartilage.  |  Zayed, N., et al. 2008. Arthritis Res Ther. 10: R146. PMID: 19094210
5. Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase.  |  Weber, JE., et al. 2010. Eur J Med Chem. 45: 447-54. PMID: 19939518
6. Differential expression of prostaglandin D2 synthase (PTGDS) in patients with attention deficit-hyperactivity disorder and bipolar disorder.  |  Marín-Méndez, JJ., et al. 2012. J Affect Disord. 138: 479-84. PMID: 22370065
7. The lipocalin-type prostaglandin D2 synthase knockout mouse model of insulin resistance and obesity demonstrates early hypothalamic-pituitary-adrenal axis hyperactivity.  |  Evans, JF., et al. 2013. J Endocrinol. 216: 169-80. PMID: 23151358
8. Modulation of lipocalin-type prostaglandin D2 synthase expression in catfish seminal vesicles by thyroid disrupting agents and hormones.  |  Sreenivasulu, G., et al. 2013. Comp Biochem Physiol C Toxicol Pharmacol. 158: 199-206. PMID: 23973827
9. Identification of indole inhibitors of human hematopoietic prostaglandin D2 synthase (hH-PGDS).  |  Edfeldt, F., et al. 2015. Bioorg Med Chem Lett. 25: 2496-500. PMID: 25978964
10. Delay in hepatocyte proliferation and prostaglandin D2 synthase expression for cholestasis due to endotoxin during partial hepatectomy in rats.  |  Wakasa, Y., et al. 2019. Mol Med Rep. 20: 4367-4375. PMID: 31545425

The preferred PGD2 synthase antibody is PGD2 synthase Antibody (F-7): sc-390717.