PFKFB3 Antibody (3F3): sc-293477

PFK-2 br/pl Antibody (3F3) is a mouse monoclonal IgG2a kappa light chain antibody that detects PFK-2 br/pl of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-PFK-2 br/pl antibody (3F3) is available as a non-conjugated format. Phosphofructosekinase-2 (PFK-2) plays a crucial role in cellular metabolism by regulating fructose 2,6-bisphosphate (F2,6BP) levels, a key metabolite that activates 6-phosphofructo-1-kinase, promoting glycolysis. PFK-2′s ability to catalyze fructose-6-phosphate phosphorylation to produce F2,6BP maintains balance between glycolytic and gluconeogenic pathways under varying physiological conditions. PFK-2 exists in several tissue-specific isoforms, including brain, liver, and placenta variants, each differentially regulated and functioning as a homodimer. iPFK-2, a unique isoform, is induced by proinflammatory stimuli and constitutively expressed in various carcinoma cell lines, leading to intracellular F2,6BP accumulation. This accumulation associates with increased DNA synthesis, suggesting iPFK-2′s role in cellular transformation and enhanced proliferation, making iPFK-2 a potential target for therapeutic intervention in cancer and metabolic disorders.

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PFKFB3 Antibody (3F3) References:

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