Date published: 2025-12-16

1-800-457-3801

SCBT Portrait Logo
Seach Input

PFK Inhibitors

Santa Cruz Biotechnology now offers a broad range of PFK Inhibitors for use in various applications. PFK Inhibitors are essential tools for studying phosphofructokinase (PFK), a key regulatory enzyme in the glycolytic pathway. PFK catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate, a crucial step in glycolysis that controls the rate of glucose metabolism. By inhibiting PFK, researchers can modulate glycolytic flux and investigate the metabolic and regulatory mechanisms governing cellular energy production. These inhibitors are invaluable for exploring how cells adjust their metabolic pathways in response to varying energy demands and environmental conditions. In scientific research, PFK Inhibitors are used to study the intricate regulation of glycolysis and its impact on cellular physiology, including ATP production, biosynthesis, and redox balance. Researchers employ these inhibitors to understand how metabolic reprogramming occurs in different cell types, such as during cellular differentiation, proliferation, and stress responses. Additionally, PFK Inhibitors are used in metabolic flux analysis to quantify changes in metabolic pathway activities under various experimental conditions. These inhibitors help explain the role of glycolysis in overall cellular metabolism and its interactions with other metabolic pathways, such as the tricarboxylic acid (TCA) cycle and oxidative phosphorylation. By providing insights into the regulation of PFK and glycolysis, these inhibitors support the development of new research methodologies and enhance our understanding of cellular metabolism. View detailed information on our available PFK Inhibitors by clicking on the product name.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Sodium Orthovanadate

13721-39-6sc-3540
sc-3540B
sc-3540A
5 g
10 g
50 g
$45.00
$56.00
$183.00
142
(4)

Sodium Orthovanadate acts as a potent inhibitor of phosphofructokinase (PFK), engaging in unique interactions that disrupt the enzyme's regulatory mechanisms. Its ability to mimic phosphate groups allows it to bind to key sites, altering the enzyme's conformation and affecting substrate affinity. This interaction influences glycolytic pathways, demonstrating distinct kinetic properties that can shift metabolic flux. The compound's structural characteristics enhance its specificity in modulating enzymatic activity.

2,5-Anhydro-D-glucitol-1,6-diphosphate

4429-47-4sc-220805
sc-220805A
sc-220805B
5 mg
10 mg
25 mg
$1438.00
$2866.00
$4090.00
(0)

2,5-Anhydro-D-glucitol-1,6-diphosphate serves as a crucial allosteric regulator of phosphofructokinase (PFK), engaging in specific molecular interactions that stabilize the enzyme's active form. By binding to allosteric sites, it induces conformational changes that enhance substrate binding and catalytic efficiency. This compound's unique structural features facilitate its role in modulating glycolytic flux, showcasing distinct kinetic profiles that influence metabolic pathways.

Itaconic acid

97-65-4sc-250207
sc-250207A
100 g
1 kg
$28.00
$51.00
(0)

Itaconic acid acts as a potent allosteric modulator of phosphofructokinase (PFK), influencing its activity through unique molecular interactions. Its distinct dicarboxylic structure allows for effective binding at regulatory sites, promoting conformational shifts that optimize enzyme functionality. This compound's ability to alter reaction kinetics enhances glycolytic regulation, showcasing its role in metabolic control and the intricate balance of energy production within cellular pathways.