Peroxin 5 Antibody (E-8): sc-390294

Peroxin 5 Antibody (E-8) is a mouse monoclonal IgG1 antibody that detects Peroxin 5 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Peroxin 5, also known as the peroxisome targeting signal 1 (PTS1) receptor, plays a crucial role in the import of proteins into peroxisomes, which are essential organelles involved in various metabolic processes, including the breakdown of fatty acids and the detoxification of hydrogen peroxide. Peroxin 5 is primarily located in the cytosol, where Peroxin 5 interacts with cargo proteins containing the PTS1 signal, facilitating their transport to the peroxisome. This localization is vital because peroxisomes are responsible for critical metabolic functions, and any disruption in their protein import can lead to severe metabolic disorders. Mutations in the Pex5 gene, which encodes Peroxin 5, are associated with Zellweger syndrome, a serious condition characterized by neurological dysfunction and early mortality. Anti-Peroxin 5 antibody (E-8) is an invaluable tool for researchers studying peroxisome biogenesis and related disorders, providing insights into the mechanisms of protein transport and the implications of Pex5 dysfunction in human health.

The preferred Peroxin 5 antibody is Peroxin 5 Antibody (B-3): sc-137103.