Peroxin 26 Antibody (C-7): sc-376589
- Peroxin 26 Antibody (C-7) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 3-27 at the N-terminus of Peroxin 26 of human origin
- recommended for detection of Peroxin 26 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG2b BP-HRP is the preferred secondary detection reagent for Peroxin 26 Antibody (C-7) for WB applications. This reagent is now offered in a bundle with Peroxin 26 Antibody (C-7) (see ordering information below).
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Peroxin 26 Antibody (C-7) is a mouse monoclonal IgG2b antibody that detects Peroxin 26 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Peroxin 26, also known as PEX26, plays a crucial role in peroxisome biogenesis by recruiting and anchoring Peroxin 1 and Peroxin 6 to the peroxisome membrane, facilitating the formation of heteromeric AAA ATPase complexes. These complexes are essential for the import of various proteins, including catalase, into peroxisomes, which are vital for cellular metabolism and detoxification processes. Proper functioning of Peroxin 26 is critical for normal development, as defects in PEX26 can lead to severe peroxisome-related disorders such as Zellweger syndrome, infantile Refsum disease, and peroxisome biogenesis disorder complementation group 8. Peroxin 26 (C-7) antibody serves as an invaluable tool for researchers studying the mechanisms of peroxisome function and the implications of peroxisomal disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Peroxin 26 Antibody (C-7) References:
- Alternative splicing suggests extended function of PEX26 in peroxisome biogenesis. | Weller, S., et al. 2005. Am J Hum Genet. 76: 987-1007. PMID: 15858711
- Conserved targeting information in mammalian and fungal peroxisomal tail-anchored proteins. | Buentzel, J., et al. 2015. Sci Rep. 5: 17420. PMID: 26627908
- Isoform-specific domain organization determines conformation and function of the peroxisomal biogenesis factor PEX26. | Guder, P., et al. 2019. Biochim Biophys Acta Mol Cell Res. 1866: 518-531. PMID: 30366024
- A newly identified mutation in the PEX26 gene is associated with a milder form of Zellweger spectrum disorder. | Tanaka, AJ., et al. 2019. Cold Spring Harb Mol Case Stud. 5: PMID: 30446579
- A novel mutation in the PEX26 gene in a family from Dagestan with members affected by Zellweger spectrum disorder. | Semenova, NA., et al. 2021. Mol Genet Metab Rep. 27: 100754. PMID: 33912394
- Identification of a Homozygous PEX26 Mutation in a Heimler Syndrome Patient. | Kim, YJ., et al. 2021. Genes (Basel). 12: PMID: 33926089
- Silencing PEX26 as an unconventional mode to kill drug-resistant cancer cells and forestall drug resistance. | Dahabieh, MS., et al. 2022. Autophagy. 18: 540-558. PMID: 34074205
- PEX26 gene genotype-phenotype correlation in neonates with Zellweger syndrome. | He, Y., et al. 2021. Transl Pediatr. 10: 1825-1833. PMID: 34430430
- Edgetic Perturbations Contribute to Phenotypic Variability in PEX26 Deficiency. | Lotz-Havla, AS., et al. 2021. Front Genet. 12: 726174. PMID: 34804114
- PEX26 Functions as a Metastasis Suppressor in Colorectal Cancer. | Yan, B., et al. 2024. Dig Dis Sci. 69: 112-122. PMID: 37957408
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Peroxin 26 Antibody (C-7) | sc-376589 | 200 µg/ml | $322.00 | |||
Peroxin 26 Antibody (C-7): m-IgG2b BP-HRP Bundle | sc-548601 | 200 µg Ab; 10 µg BP | $361.00 | |||
Peroxin 26 (C-7) Neutralizing Peptide | sc-376589 P | 100 µg/0.5 ml | $69.00 |