Peroxin 14 Antibody (1G12): sc-293383

Peroxin 14 Antibody (1G12) is a mouse monoclonal IgG2a kappa light chain antibody that detects Peroxin 14 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Peroxin 14 antibody (1G12) is available as the non-conjugated format. Peroxin 14 plays a crucial role in peroxisome biogenesis, serving as a docking site for proteins that contain peroxisome targeting signals. Located on the peroxisomal membrane, Peroxin 14 is essential for the import of various enzymes and proteins into peroxisomes, which are vital organelles involved in lipid metabolism and the detoxification of reactive oxygen species. Peroxin 14 facilitates the transport of proteins like Peroxin 5 and Peroxin 7, which are responsible for recognizing and shuttling proteins with peroxisome targeting signals from the cytosol into the peroxisome. Disruptions in Peroxin 14 function can lead to severe metabolic disorders, including peroxisome biogenesis disorders, which are characterized by a range of neurological and developmental issues. Peroxin 14′s role in maintaining cellular homeostasis and involvement in critical metabolic pathways underscore its significance in both health and disease, making Peroxin 14 (1G12) antibody a valuable tool for researchers studying peroxisome-related functions and disorders.

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Peroxin 14 Antibody (1G12) References:

1. Involvement of Pex13p in Pex14p localization and peroxisomal targeting signal 2-dependent protein import into peroxisomes.  |  Girzalsky, W., et al. 1999. J Cell Biol. 144: 1151-62. PMID: 10087260
2. Peroxisome biogenesis and peroxisome biogenesis disorders.  |  Fujiki, Y. 2000. FEBS Lett. 476: 42-6. PMID: 10878247
3. The peroxisome biogenesis factors pex4p, pex22p, pex1p, and pex6p act in the terminal steps of peroxisomal matrix protein import.  |  Collins, CS., et al. 2000. Mol Cell Biol. 20: 7516-26. PMID: 11003648
4. Organelle disease: peroxisomal disorders.  |  Gärtner, J. 2000. Eur J Pediatr. 159 Suppl 3: S236-9. PMID: 11216907
5. The peroxisome deficient PEX2 Zellweger mouse: pathologic and biochemical correlates of lipid dysfunction.  |  Faust, PL., et al. 2001. J Mol Neurosci. 16: 289-97; discussion 317-21. PMID: 11478384
6. Domain mapping of human PEX5 reveals functional and structural similarities to Saccharomyces cerevisiae Pex18p and Pex21p.  |  Dodt, G., et al. 2001. J Biol Chem. 276: 41769-81. PMID: 11546814
7. Mitochondrial alterations caused by defective peroxisomal biogenesis in a mouse model for Zellweger syndrome (PEX5 knockout mouse).  |  Baumgart, E., et al. 2001. Am J Pathol. 159: 1477-94. PMID: 11583975
8. Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import.  |  Otera, H., et al. 2002. Mol Cell Biol. 22: 1639-55. PMID: 11865044
9. Cellular and molecular aspects of Zellweger syndrome and other peroxisome biogenesis disorders.  |  Brosius, U. and Gärtner, J. 2002. Cell Mol Life Sci. 59: 1058-69. PMID: 12169017